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SYNAPS

Financiado

Cerrado

Synthetic Neurons and Artificial Photoactivated Synapses

The brain is a complex network of inter-connected neurons that communicate through synapses. SYNAPS aims to for the first time mimic such synapses using liposomes as artificial cells, and visible light to trigger a signal from a ‘... ver más

30/09/2028

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSIDAD DE BARCELONA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 328

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-12-05

ERC-2022-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada hace 3 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

1.69M€ | Lider

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Duración del proyecto: 69 meses Fecha Inicio: 2022-12-05
Fecha Fin: 2028-09-30

Líder del proyecto

UNIVERSIDAD DE BARCELONA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 328

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The brain is a complex network of inter-connected neurons that communicate through synapses. SYNAPS aims to for the first time mimic such synapses using liposomes as artificial cells, and visible light to trigger a signal from a ‘sender’- to a ‘receiver’-liposome. Mimicking such communication processes will help with understanding how complex natural emergent properties arise, and could ultimately allow for the construction of a chemical computer. SYNAPS will excel beyond the state-of-the-art by maintaining chemical isolation between liposome interiors, ensuring local, time-bound communication between connected liposomes, and using light as an external stimulus and fuel. These concepts are essential to construct artificial tissues that can communicate on an individual liposome-to-liposome basis, in contrast to the state-of-the-art where communication generally occurs with the bulk solution. To achieve this, a messenger compound will be locally photosynthesised through transmembrane electron transfer by porphyrin dimers that portray a charge-transfer excited state. The liposomes will be organised into a synaptic cleft through the use of synthetic complementary clustering compounds that provide stable adhesion between sender and receiver liposomes. The messenger compound will be recognised by reversible and selective membrane-spanning receptors in the receiver liposome, that will output the signal through fluorescence. In addition, a reaction cascade network will be constructed involving the messenger to produce an artificial action potential, that is, a transient peak in the concentration of the messenger, ensuring a time-bound dissipative signal. Altogether, SYNAPS will provide advances in systems chemistry by providing a nanoscale platform for communication between chemically isolated systems, but also results that are useful for applications such as light-to-chemical energy conversion, chemical sensing and smart drug-delivery.

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