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SynAb4Toxin

Financiado

Synthetic antibody (SynAb) receptors for the detection and isolation of cyclic d...

Synthetic antibody (SynAb) receptors for the detection and isolation of cyclic depsipeptide (CDP) toxins in food samples Food safety plays a critical role in society. When it comes to avoiding food poisoning, most of the attention goes to preventing microbial growth in food products. However, the cause of intoxication is the presence of toxins produ... ver más

31/03/2025

UGent

176K€

Presupuesto del proyecto: 176K€

Líder del proyecto

UNIVERSITEIT GENT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-07

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 ExpectedOutcome:

I+D

Cerrada hace 2 años

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1 Participantes

UGent

175.92K€ | Lider

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Duración del proyecto: 24 meses Fecha Inicio: 2023-03-07
Fecha Fin: 2025-03-31

Líder del proyecto

UNIVERSITEIT GENT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 176K€

Descripción del proyecto Food safety plays a critical role in society. When it comes to avoiding food poisoning, most of the attention goes to preventing microbial growth in food products. However, the cause of intoxication is the presence of toxins produced by these microorganisms. Yet, standard industrial or household food processing and preparation techniques effective at removing the producing microorganisms fail to remove the actual toxins. As a result, these toxins, which typically are not detected in routine microbial food analysis, are consumed daily by the general population. Beauvericin (BEA) and enniatin B (ENN B) are mycotoxins produced on crops that can easily end up in the final food or feed products. Other examples include cereulide (CER), which is produced by bacteria and has a high prevalence in ready-to-eat foods. Multiple consequences and even fatalities have been reported due to the consumption of food contaminated with BEA/ENN or CER and as such, the detection and sequestration of these toxins is of utmost importance, both in public health and economic terms, as well as from a broader stakeholder perspective. Despite numerous attempts worldwide, the current state of the art does not allow the production of antibodies against CER, BEA or ENN B via classical animal immunization. This hampers the creation of a fast, robust, inexpensive and on-field (kit-based) detection system for these toxins in food commodities. In the current project, I intend to use artificial synthetic antibodies (SynAbs) that bind to these toxins (ionophoric cyclic depsipeptides) to produce valuable technologies for detecting and isolating these toxins in complex food samples.

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