SINMOF
Financiado
Synthesis of Spirooxindoles and INdoles pharmaceuticals using Metal Organic Fram...
SINMOF is a pioneering and structured effort to comprehensively address the introduction of different immobilised isolated catalytic active sites in solid hybrid materials to overcome the metal losses occurring with state-of-the-a...
SINMOF is a pioneering and structured effort to comprehensively address the introduction of different immobilised isolated catalytic active sites in solid hybrid materials to overcome the metal losses occurring with state-of-the-art homogeneous catalysts employed in the pharmaceutical industry. The convenient use of hybrid metal-organic framework materials (MOFs) respect to traditional state-of-the-art porous solid materials is due to (a) self-deactivation-resistant design of the active sites by (b) ultrastable catalytic site isolation. In the SINMOF project we will (1) design novel multifunctional MOFs as next generation catalysts for the synthesis of pharmaceutically active compounds in an economically and environmentally beneficial way; (2) apply MOF hybrid solids as heterogeneous catalysts to avoid the use of homogeneous metal catalysts in novel synthetic strategies of pharmaceuticals with the indole core and finally (3) derive structure-activity and selectivity relationships at the smallest possible length scales and with the highest possible sensitivities employing fluorescence microscopy. Using a two-stage research methodology, SINMOF will finally provide the most active and stable MOF catalyst for the synthesis of the indole-based neurotransmitter Sumatriptan and the anticancerigen spirooxindole SAR405838. The combined expertise of the fellow and host ensures the best chance for successfully completing the SINMOF objectives in a mutually beneficial manner. On one side, internal collaborations at the host institution will allow the access to state-of-the-art fluorescence microscopy methods, to get new insights into the molecular mechanisms underlying the novel catalytic systems. On the other side, a secondment at a world-leading research center in the homogeneous catalysis field will train the researcher in order to individuate the best molecular features for model homogeneous catalysts to be translated into selective heterogeneous MOF catalytic system.
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Duración del proyecto: 26 meses
Fecha Inicio: 2017-03-03
Fecha Fin: 2019-05-31
Fecha Fin: 2019-05-31
Línea de financiación: concedida
El organismo H2020 notifico la concesión del proyecto el día 2019-05-31
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
MSCA-IF-2016:
Individual Fellowships
Cerrada
hace 8 años
Presupuesto
El presupuesto total del proyecto asciende a
161K€
Líder del proyecto
KATHOLIEKE UNIVERSITEIT LEUVEN
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5
600.00K€ |
Participante