SYNergize
Financiado
SYNergize: Understanding spore-forming gut bacteria biology to target pathogens
Our intestinal microbiota consists of a dense community of microorganisms, highly adapted to the human gastrointestinal tract. Shared species between individuals indicates the presence of evolved and efficient transmission routes...
Our intestinal microbiota consists of a dense community of microorganisms, highly adapted to the human gastrointestinal tract. Shared species between individuals indicates the presence of evolved and efficient transmission routes that ensure colonisation of beneficial bacterial species. Research has traditionally focussed on blocking enteric pathogen transmission routes as a means to prevent disease. However, a greater focus on understanding the transmission routes of commensal gut bacteria is required to promote health. Spores are resilient structures that maintain bacterial integrity in a dormant state for extended periods. My previous work has shown that spore-formation is a prevalent phenotype in the intestinal microbiota that promotes transmission of anaerobic gut bacteria, by maintaining viability in adverse aerobic environmental conditions until ingested by a new host. However, despite its importance, sporulation processes in commensal gut bacteria remain poorly understood.SYNergize will characterise the metabolic capabilities of gut spore-formers, spore composition and the environmental cues involved in spore formation and germination. By identifying combinations of bacteria and nutrients that inhibit enteric pathogens, SYNergize also seeks to provide new approaches to target the problem of increasing antimicrobial resistance in European healthcare systems. These probiotic isolate and prebiotic nutrient combinations can be used to create ‘synbiotics’, rationally designed and ingested to decolonise gut pathogens. A deeper understanding of sporulation processes could also allow spores to be used to effectively deliver anaerobic probiotic bacteria to the gut. By exploring transmission and colonisation processes of intestinal spore-forming bacteria, SYNergize seeks to understand fundamental adaptations of our intestinal microbiota, which could provide new tools to target antibiotic resistant pathogens.
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Duración del proyecto: 59 meses
Fecha Inicio: 2024-04-01
Fecha Fin: 2029-03-31
Fecha Fin: 2029-03-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-04-01
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
ERC-2023-STG:
ERC STARTING GRANTS
Cerrada
hace 2 años
Presupuesto
El presupuesto total del proyecto asciende a
1M€
Líder del proyecto
UNIVERSITY COLLEGE CORK NATIONAL UNIVERSITY...
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5