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SORTED

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Synbio for cOmpartmentalized caRotenoids sToragE in Diatoms

Carotenoids, prized for their antioxidant properties, are essential precursors for crucial human vitamins and, in plants and algae, they play roles in light absorption and photoprotection against excessive light-induced damage to... ver más

31/10/2026

SDU

Presupuesto desconocido

Líder del proyecto

SYDDANSK UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-11-01

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023 ExpectedOutcome:Project results are expected to contribute to the following outcomes:

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Duración del proyecto: 23 meses Fecha Inicio: 2024-11-01
Fecha Fin: 2026-10-31

Líder del proyecto

SYDDANSK UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Carotenoids, prized for their antioxidant properties, are essential precursors for crucial human vitamins and, in plants and algae, they play roles in light absorption and photoprotection against excessive light-induced damage to photosynthesis. However, it is very challenging to achieve carotenoid market- required yields. Carotenoids complex chemical synthesis in fact, limits the possibility to obtain them artificially while in plants (i.e., the main natural producers) excessive carotenoids in chloroplasts can disrupt thylakoid membranes, making biotechnological manipulation aimed to increase carotenoid yield particularly hard.To address this problem, a sustainable approach is crucial, and microalgae offer a promising solution as natural, scalable carotenoid producers. A novel strategy involves repurposing cellular factories to overcome chloroplast limitations for carotenoid biosynthesis and accumulation. Diatoms, like Phaeodactylum tricornutum, are ideal candidates due to their multiple cellular compartments, including the periplastidial compartment (PPC), suitable for carotenoid storage, and access to precursors synthesized through various cellular pathways.Moreover, diatoms excel as synthetic biology platforms with efficient genetic tools, modular DNA assembly, and genome editing capabilities.The SORTED project aims to advance understanding through a multifaceted approach. Firstly, we will investigate prenyltransferases (PTSs) in P. tricornutum's cytosol to unveil their role in carotenoid precursor synthesis (Objective 1). Subsequently, rational redesign will enable the extraplastidial relocation of the carotenoid biosynthetic pathway (Objective 2). Furthermore, we will assess the physiological implications of genetic modifications on performance (Objective 3). Through SORTED, we anticipate gaining innovative insights into diatom carotenoid production, revolutionizing both biotechnology and our fundamental understanding of cellular dynamics.

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