Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

SynPromiscuity

Financiado

Synaptic Promiscuity in Brain Development

Precise synaptic connectivity is a prerequisite for the function of neural circuits, yet individual neurons, taken out of their developmental context, readily form unspecific synapses. The goal of this proposal is to understand th... ver más

30/09/2026

Freie Universitaet...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

FREIE UNIVERSITAET BERLIN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-05-19

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2020-ADG: ERC ADVANCED GRANT

I+D

Cerrada hace 4 años

0% 100% 100%

2 Participantes

Freie Universitaet Berlin

2.30M€ | Lider

AUTOMATION SYSTEMS GROUP

383.48K€ | Participante

Últimas noticias

02-12-2024: AGENCIA-VALENCIANA-D... En las últimas 48 horas el Organismo AGENCIA VALENCIANA D... ha otorgado 1 concesiones

02-12-2024: CDTI En las últimas 48 horas el Organismo CDTI ha otorgado 4 concesiones

01-12-2024: REDES En las últimas 48 horas el Organismo REDES ha otorgado 1337 concesiones

Duración del proyecto: 64 meses Fecha Inicio: 2021-05-19
Fecha Fin: 2026-09-30

Líder del proyecto

FREIE UNIVERSITAET BERLIN

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto Precise synaptic connectivity is a prerequisite for the function of neural circuits, yet individual neurons, taken out of their developmental context, readily form unspecific synapses. The goal of this proposal is to understand the roles and requirements of such promiscuous synapse formation during brain development. The observation of promiscuous synapse formation is not at odds with precise outcomes. The developmental program can ensure correct partnerships between neurons that form synapses promiscuously, but to what degree remains largely unresolved. My group has developed live imaging and optogenetic manipulations of dynamic synaptic choice processes in the intact developing fly brain. We found that time, location and the kinetics of filopodial interactions restrict to a remarkable degree the specificity of synaptic contacts between neurons that can form synapses with many partners if not actively prevented from doing so. A second surprise finding that motivates this proposal suggests markedly different connectomes of flies that developed at 18°C and 25°C, including synapse numbers and partnerships. These differences can be traced back to interaction kinetics during development, thus revealing a level of synaptic promiscuity that can be exposed through temperature alone. The time is ripe for a quantitative assessment of the extent to which synaptic connections are the result of developmentally regulated promiscuous synapse formation. The quest to understand the molecular mechanisms of brain wiring has largely focused on guidance cues and synaptic recognition, fields in which great progress continues to be made. This proposal offers to approach the question of synaptic specificity from the much rarer, but complementary perspective of the alternative limiting case, the hypothesis of synaptic promiscuity. SynPromiscuity is devised to balance the risks of a contrarian approach with its relevance for neurodevelopmental precision and plasticity in health and disease.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores