Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

SynPromiscuity

Financiado

Cerrado

Synaptic Promiscuity in Brain Development

Precise synaptic connectivity is a prerequisite for the function of neural circuits, yet individual neurons, taken out of their developmental context, readily form unspecific synapses. The goal of this proposal is to understand th... ver más

30/09/2026

Freie Universitaet...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

FREIE UNIVERSITAET BERLIN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-05-19

ERC-2020-ADG: ERC ADVANCED GRANT

I+D

Cerrada hace 4 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

Freie Universitaet Berlin

2.30M€ | Lider

AUTOMATION SYSTEMS GROUP

383.48K€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

OMFLICSS Functional long term imaging of single bouton spine pairs du... 180K€ Cerrado

BrainRedesign Redesigning brain circuits in development 2M€ Cerrado

PrefrontalMap Organization and learning associated dynamics of prefrontal... 2M€ Cerrado

PhotoXLink Development of biomolecular tools for the spatiotemporal pho... 185K€ Cerrado

DENDRITE2BEHAVIOR From dendrite to behavior fiberoptic Imaging and optogeneti... 169K€ Cerrado

DEFINE DEciphering mechanisms of presynaptic reFINEment 173K€ Cerrado

Duración del proyecto: 64 meses Fecha Inicio: 2021-05-19
Fecha Fin: 2026-09-30

Líder del proyecto

FREIE UNIVERSITAET BERLIN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Precise synaptic connectivity is a prerequisite for the function of neural circuits, yet individual neurons, taken out of their developmental context, readily form unspecific synapses. The goal of this proposal is to understand the roles and requirements of such promiscuous synapse formation during brain development. The observation of promiscuous synapse formation is not at odds with precise outcomes. The developmental program can ensure correct partnerships between neurons that form synapses promiscuously, but to what degree remains largely unresolved. My group has developed live imaging and optogenetic manipulations of dynamic synaptic choice processes in the intact developing fly brain. We found that time, location and the kinetics of filopodial interactions restrict to a remarkable degree the specificity of synaptic contacts between neurons that can form synapses with many partners if not actively prevented from doing so. A second surprise finding that motivates this proposal suggests markedly different connectomes of flies that developed at 18°C and 25°C, including synapse numbers and partnerships. These differences can be traced back to interaction kinetics during development, thus revealing a level of synaptic promiscuity that can be exposed through temperature alone. The time is ripe for a quantitative assessment of the extent to which synaptic connections are the result of developmentally regulated promiscuous synapse formation. The quest to understand the molecular mechanisms of brain wiring has largely focused on guidance cues and synaptic recognition, fields in which great progress continues to be made. This proposal offers to approach the question of synaptic specificity from the much rarer, but complementary perspective of the alternative limiting case, the hypothesis of synaptic promiscuity. SynPromiscuity is devised to balance the risks of a contrarian approach with its relevance for neurodevelopmental precision and plasticity in health and disease.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores