Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

SYNAPSE TRANSMISSION

Financiado

Cerrado

Synaptic mechanisms underlying neural coding in the retina during visual respons...

Synaptic mechanisms underlying neural coding in the retina during visual response A formidable challenge for the visual system is to encode the statistical variability in the visual environment. For example, the vital statistics of contrast and luminance vary by several orders of magnitude within an image and d... ver más

28/02/2015

UOS

231K€

Presupuesto del proyecto: 231K€

Líder del proyecto

THE UNIVERSITY OF SUSSEX No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-02-28 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

UOS

0.00€ | Lider

NC3Rs

N.D. | Participante

Proyectos interesantes

S1PERCEP

Medical Technol...

Applied Physics

100K€ Cerrado

VESTIBCELLDYNAMICS

Medical Technol...

Applied Physics

166K€ Cerrado

NeuroOptoGen

Medical Technol...

Applied Physics

2M€ Cerrado

EUROV1SION

Medical Technol...

Applied Physics

3M€ Cerrado

Eye to Action

Medical Technol...

Applied Physics

2M€ Cerrado

OscillatoryVision

Medical Technol...

Applied Physics

1M€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

THE UNIVERSITY OF SUSSEX No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 231K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto A formidable challenge for the visual system is to encode the statistical variability in the visual environment. For example, the vital statistics of contrast and luminance vary by several orders of magnitude within an image and during global changes in overall viewing conditions. The range of visual signals far exceeds the dynamic range of neurons in the retina. Traditional views dictate that during the visual contrast processing the retinal circuitry undergoes adaptation and thereby extends its dynamic range. This is intuitively appealing. However, recent studies have demonstrated an opposite form of plasticity – facilitation. Both adaptation and facilitation originate at the synaptic terminals of the bipolar cells. A combination of adaptation and facilitation might help to detect both an increase and decrease in contrast. However, the mechanisms underlying such plasticity and subsequent neural coding are largely unknown and my work will focus on studying these questions. This requires studying the properties of synaptic terminals of bipolar cells and that of amacrine cells which provide lateral inhibitory input. I shall use multiphoton microscopy to do in vivo measurements in the retina of zebrafish larvae. I shall monitor calcium signals and exo-and endocytosis of neurotransmitter vesicles at the synaptic terminals of both bipolar and amacrine cells under spatio-temporally different contrast illuminations. The calcium signals and vesicle activity will be simultaneously monitored using novel genetically encoded reporters of varying spectral properties. Secondly, I shall study the role of various neurotransmitters in modulating synaptic activity. Finally, I shall study how opposite forms of plasticity segregate into different layers of the retinal circuitry. Similar challenges for neural coding exist in other sensory systems. The insights gained from studying synaptic bases of neural coding in the retina will improve our general understanding of neural function.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores