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Suspended Fluidic nanochannels as optomechanical sensors for single molecules

Early detection of cancer saves lives: the survival rate increases from 10% to 90%. Today, there is a lack of methods for the early detection of different types of cancer. The main challenge is that a large variety of specific bi... ver más

30/04/2024

UHAM

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSITY OF HAMBURG No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2024-04-30

ERC-2016-STG: ERC Starting Grant Scope:Objectives

I+D

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2 Participantes

UHAM

1.50M€ | Lider

MECANICA COMERCIAL MECO

239.65K€ | Participante

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Duración del proyecto: 83 meses Fecha Inicio: 2017-05-08
Fecha Fin: 2024-04-30

Líder del proyecto

UNIVERSITY OF HAMBURG No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Early detection of cancer saves lives: the survival rate increases from 10% to 90%. Today, there is a lack of methods for the early detection of different types of cancer. The main challenge is that a large variety of specific biomarkers have to be counted, and usually at extremely low concentrations. Here we will use smart nanoengineering to develop a versatile sensing platform that detects, identifies and counts single molecules, one by one, in a non-purified solution. The main novelty of the proposal is that the platform will integrate optical sensing beyond diffraction (for biochemical recognition) and on-chip molecular mass sensing (to discard non-specific binding events). For this, we will suspend state-of-the-art nanochannels and integrate them with plasmonic nano-antennas. This will make for a versatile, universal test, cheap enough to be used for preventive screening. It will help diagnosing different types of cancers earlier. We will detect and identify oncoviruses capsides, different protein biomarkers and microRNA in plasma. These are very high impact proof of concepts with clinical relevance. Dr. Fernandez-Cuesta has expertise in single molecule sensing and has worked in multiple international, interdisciplinary environments. She is expert in nanofabrication and plasmonics for (bio)sensing. She benefited from an IOF Marie Curie. She became CEO and co-founder of a start-up, dedicated to on-chip Raman spectroscopy for environmental monitoring of biotoxins concentration in fresh water. Currently, she is at the department for Applied Physics at the University of Hamburg. There, there is state-of-the-art instrumentation for nanofabrication. The collaborators at Hamburg University Klinikum Eppendorf have expertise in applying research to medicine. This interdisciplinary environment is ideal for starting a new field in combined plasmonics and mass sensing with a focus on nanotechnology for bioapplications of clinical relevance.

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