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FuncAmyloid

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Structure, Function and Regulation of Antimicrobial and Virulent Amyloids at Hig...

Structure, Function and Regulation of Antimicrobial and Virulent Amyloids at High-resolution Self-assembly of proteins and peptides into amyloid fibrils produced across kingdoms of life is associated with antimicrobial activity, microbial pathogenicity, and a wide range of diseases. The correlation of fibrillation and mor... see more

30/09/2028

DESY

2M€

Project Budget: 2M€

Project leader

DEUTSCHES ELEKTRONENSYNCHROTRON DESY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo HORIZON EUROPE notifico la concesión del proyecto The day 2023-03-31

ERC-2022-COG: ERC CONSOLIDATOR GRANTS Scope:Objectives

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

DESY

2.00M€ | Leader

EMBL

N.D. | participant

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Project duration: 65 months Date Start: 2023-03-31
End date: 2028-09-30

Project leader

DEUTSCHES ELEKTRONENSYNCHROTRON DESY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 2M€

participation deadline Sin fecha límite de participación.

Project description Self-assembly of proteins and peptides into amyloid fibrils produced across kingdoms of life is associated with antimicrobial activity, microbial pathogenicity, and a wide range of diseases. The correlation of fibrillation and morphology to function is poorly understood, and high-resolution structural information and mechanistic models are lacking. Our lab pioneered the atomic-level analysis of bacterial amyloids and eukaryotic functional fibrils involved in cytotoxicity, biofilm structuring, and antibacterial activity. We revealed novel morphologies extending beyond canonical amyloid cross-β structures of tightly mated β-sheets, to include, for example, cross-α fibrils composed on amphipathic α-helices. In addition, we exposed a unique lipid-induced cross-α/β secondary structure switch in fibrils of the same sequence. Here we investigate amyloid fibrils which serve as key virulence determinants in S. aureus and Pseudomonas acting as cytotoxins and in biofilm scaffolding, and as antimicrobials produced across different species. We will leverage the knowledge and expertise, and newly emerging methods in electron, light and force microscopy, to understand how fibrillation propensity, fibril morphology and structural switches are connected to function, membrane interactions and toxicity mechanisms at high resolution. The findings are expected to identify structural features that underlie the formation, regulation, and activity of these fibrils, providing advantages in specific environments. Understanding these structure-function relationships will help to clarify the link between amyloid formation and antimicrobial activity. We will use the insights gained from these studies for the rational design of antimicrobial peptides and small molecules targeting virulent determinants towards potential applications in the management of infectious diseases. Our findings on functional amyloids can overall advance life, material, medical and environmental sciences.

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