Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MEMBRANEFUSION

Financiado

Structure and mechanism of viral and cellular membrane fusion machineries

Fusion of two biological membranes is essential to life. It is required during organism development, for trafficking of material between cellular compartments, for transfer of information across synapses, and for entry of viruses... ver más

31/08/2021

UKRI

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNITED KINGDOM RESEARCH AND INNOVATION No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 3 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-08-31

ERC-CoG-2014: ERC Consolidator Grant

I+D

Cerrada hace 10 años

0% 100% 100%

3 Participantes

UKRI

1.79M€ | Lider

NICOLAS CORREA

1.53M€ | Participante

EMBL

180.00K€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

MEMLESSINTERFACE Interface between Membraneless Organelles and Membranes 1M€ Cerrado

BFU2015-64541-R DESCIFRANDO LOS PROCESOS DEL CICLO VITAL DE VIRUS CON MEMBRA... 175K€ Cerrado

HYDROBIOMEM Hydrodynamics of Double Membrane Spreading in Biology 211K€ Cerrado

PGC2018-099857-B-I00 INTERACCIONES MOLECULARES EN MEMBRANAS Y PAPEL DE LOS ESFING... 159K€ Cerrado

BFU2012-34885 ESTEQUIOMETRIA Y EL MECANISMO DE ACCION DE LA DINAMINA DURAN... 187K€ Cerrado

MitoMeChAnics Deciphering the role of surface mechanics during cell divisi... 2M€ Cerrado

Duración del proyecto: 76 meses Fecha Inicio: 2015-04-01
Fecha Fin: 2021-08-31

Líder del proyecto

UNITED KINGDOM RESEARCH AND INNOVATION No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto Fusion of two biological membranes is essential to life. It is required during organism development, for trafficking of material between cellular compartments, for transfer of information across synapses, and for entry of viruses into cells. Fusion must be carefully controlled and the core fusion components are typically found within a complex regulatory machine. There have been decades of research on the structure and function of individual components, on the dynamics and biophysics of fusion, and on phenotypes resulting from mutating or inhibiting component proteins. These have led to a model for fusion in which regulated refolding or assembly of proteins draws two membranes closer together until they fuse. Despite this breadth of study, we know very little about how the components of the fusion machinery function in context: How are they arranged on the membrane around the site of fusion? How do they respond structurally to regulation? How does the fully assembled machinery rearrange to reshape the membrane and drive fusion? These gaps in knowledge can be attributed to a shortage of structural biology methods able to derive structural data on proteins assembled within complex, heterogeneous or dynamic environments such as a fusion site. Here I propose to apply a combination of state-of-the-art cryo-electron tomography, image processing and correlative fluorescence and electron microscopy methods to obtain detailed structural information on assembled fusion machineries and of fusion intermediates both in vitro and in vivo. I will study how influenza virus fuses with a target membrane, complemented by studies on fusion of HIV-1 and of synaptic vesicles. By determining how viral and synaptic fusion complexes reposition and restructure prior to fusion, how they arrange around the fusion site, how they reshape the membrane to induce fusion, and how these processes can be regulated and inhibited, I will derive a mechanistic model of membrane fusion in situ.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores