Hola,
Are you new here?

I have an account

Conecta con

+150K Projects

+300K Companies

+230 Financiaciones

¿Te ayudamos?

Ejemplos de búsqueda

Vídeos Explicativos

VaxVision

financed

Closed

Structure and Function based Design of Vaccine Antigens and Antiviral Immunother...

Structure and Function based Design of Vaccine Antigens and Antiviral Immunotherapies Vaccines are critical in preventing viral diseases, and recent advances in vaccine development and delivery platforms have enhanced their reach and efficacy. Viral glycoproteins that mediate host cell entry are the primary target... see more

31/12/2029

unknown leader

1M€

Project Budget: 1M€

Project leader unknown leader

PARTICIPATION DEPralty Sin fecha límite de participación.

Financing granted El organismo HORIZON EUROPE notifico la concesión del proyecto The day 2024-10-28

ERC-2024-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada does 1 year

0% 100% 100%

characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

KAROLINSKA INSTITUTET

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Project duration: 62 months Date Start: 2024-10-28
End date: 2029-12-31

Project leader unknown leader

Project Budget 1M€

participation deadline Sin fecha límite de participación.

Project description Vaccines are critical in preventing viral diseases, and recent advances in vaccine development and delivery platforms have enhanced their reach and efficacy. Viral glycoproteins that mediate host cell entry are the primary target of the humoral immune response and thus the main antigenic component of vaccines. However, for many viruses, we lack fundamental biological insights that would easily allow transforming their glycoproteins into highly effective vaccine antigens. In this proposal, I introduce a completely novel approach to thoroughly extract structural and functional insights of viral glycoproteins for rational design of superior antigens. By conducting nanobody repertoire screens, I will bypass common constraints encountered in antibody screening, such as immunodominance bias and redundancy. Contrasting with conventional techniques that narrowly target a limited selection of epitopes, my approach promises an exhaustive mapping of glycoprotein surfaces and epitopes. This paradigm shift enables antigen rather than antibody or nanobody characterization. By determining high-resolution cryoEM structures of nanobodies bound to glycoproteins in transitional states, we will understand their structural dynamics. Equipped with these unparalleled insights, we will harness pioneering deep learning methods to computationally design glycoproteins with enhanced antigenic form and exposed neutralizing surfaces. I will showcase this method for viruses with high case fatality rates, including Hendra, Nipah, Lassa, Tick-borne encephalitis, and Borna disease viruses. VaxVision is set to offer a comprehensive framework for the antigen design of these and genetically or structurally related viruses. My work aims to capitalize on the unused potential for vaccine antigen improvement and will provide an innovative workflow for extracting mechanistic insights and leveraging them for vaccine antigen design, with the potential to drive vaccine innovations beyond just viral pathogens.

Conecta tu I+D

Entra hoy

Forgot your password?

Financing

Companies

CTIs/Universidades

Projects

researchers

What is innovating.Works? Lose yourself in the best search engine for innovative companies you've ever seen, see how your competition is funded, connect with that partner you didn't know about, discover R&D projects that need you, and much, much more just a click away.

Smart Company-Financial Motor Innovating tiene un perfil tecnológico financiero de 400.000 empresas gracias al cual sabe a qué ayuda puede ir o no cualquier empresa de forma automática. Parece magia pero es tecnología.

Create your project and find partners ¿Tienes un proyecto y buscas un partner? Una Universidad, Centro Tecnológico, Consultoría? Este es tu sitio. Gracias al motor de búsqueda podemos recomendarte los mejores socios y ponerte en contacto con ellos.