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HeartRepairKIT

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Structural, kinetic, and biophysical analysis and engineering of KIT.METRNL sign...

Structural, kinetic, and biophysical analysis and engineering of KIT.METRNL signalling to boost heart tissue regeneration after myocardial infarction KIT, a receptor tyrosine kinase, is dimerized at the cell surface by the cytokine stem cell factor (SCF) to initiate signalling pathways securing fundamental cellular processes, including hematopoiesis, gametogenesis, and melanoge... ver más

31/03/2026

VLAAMS INSTITUUT...

192K€

Presupuesto del proyecto: 192K€

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TRL 4-5

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Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-03-04

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023

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2 Participantes

VLAAMS INSTITUUT BIOTECHNOL...

191.76K€ | Lider

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Últimas noticias

30-11-2024: Cataluña Gestión For... Se ha cerrado la línea de ayuda pública: Gestión Forestal Sostenible para Inversiones Forestales Productivas para el organismo:

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

Duración del proyecto: 24 meses Fecha Inicio: 2024-03-04
Fecha Fin: 2026-03-31

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VIB VZW

TRL 4-5

Presupuesto del proyecto 192K€

Descripción del proyecto KIT, a receptor tyrosine kinase, is dimerized at the cell surface by the cytokine stem cell factor (SCF) to initiate signalling pathways securing fundamental cellular processes, including hematopoiesis, gametogenesis, and melanogenesis. Impaired signalling due to KIT mutations or deficiency leads to various malignancies such as leukemia and melanoma. However, recent data have shown that KIT can also initiate signalling by binding meteorin-like protein (METRNL), triggering unrelated stimulation of heart tissue regeneration. Ischemic heart diseases are the leading cause of mortality and morbidity worldwide, with approximately 9 million annual deaths and over 180 million disability-adjusted life years lost. Therefore, revealing the molecular principles and mechanism of this completely new function of KIT gives hope for new opportunities towards novel therapies that might maximize the efficiency of heart recovery after heart disease incidence. However, the field is currently plagued by a paucity of mechanistic details and the structure-function relationship of the KIT.METRNL complex assembly. The goal of this project is to derive the structure-function landscape of the novel interaction between KIT and METRNL and to provide a blueprint for how KIT can be activated by two structurally distinct protein ligands. The gained knowledge will govern the rational engineering of METRNL towards improving its interaction with KIT to elicit intensified signalling that can lead to amplified heart tissue regeneration. This aim will be achieved by synergistically combining methods of molecular and structural biology (supervisor’s expertise), biomolecular kinetics and rational protein engineering (researcher’s experience), and single molecule biophysics (secondment). Collectively, this research endeavour will impact basic and applied cardiovascular disease research and promises to provide new possibilities for alleviating the enormous socioeconomic burden associated with these diseases.

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