Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

SARPBAXZ

Financiado

Cerrado

Structural analysis of Rad51 paralogues involved in recombinational DNA repair

Homologous recombination (HR) is a major mechanism for repairing DNA double-strand breaks (DSBs). A DSB converts one normal chromosome into two pathological chromosomes, making it the severest form of DNA damage. Accordingly, defe... ver más

30/04/2023

IMPERIAL COLLEGE O...

225K€

Presupuesto del proyecto: 225K€

Líder del proyecto

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND ME... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-04-30

MSCA-IF-2020: Individual Fellowships

I+D

Cerrada hace 4 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

IMPERIAL COLLEGE OF SCIENCE...

224.93K€ | Lider

Proyectos interesantes

FIS2014-51481-ERC

Medical Technol...

Applied Physics

85K€ Cerrado

MULTIPLE SEARCH

Medical Technol...

Applied Physics

280K€ Cerrado

DEFACT

Medical Technol...

Applied Physics

2M€ Cerrado

BRCA2Interact

Medical Technol...

Applied Physics

183K€ Cerrado

BrokenGenome

Medical Technol...

Applied Physics

1M€ Cerrado

BRCA INSIGHTS

Medical Technol...

Applied Physics

2M€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 25 meses Fecha Inicio: 2021-03-18
Fecha Fin: 2023-04-30

Líder del proyecto

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND ME... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 225K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Homologous recombination (HR) is a major mechanism for repairing DNA double-strand breaks (DSBs). A DSB converts one normal chromosome into two pathological chromosomes, making it the severest form of DNA damage. Accordingly, defects in HR lead to genome instability, a potent driver of tumorigenesis. Although Rad51 is the central enzyme involved in HR, several auxiliary factors promote HR by stimulating Rad51. Rad51 paralogs comprise one family of evolutionarily conserved auxiliary factor. Unlike other auxiliary factors, Rad51 paralogs are notorious for their biochemical intractability, a trait that has greatly hindered progress in understanding their function, which in turn has precluded a more complete understanding of HR as a whole. This proposal aims to uncover the molecular mechanisms underlying Rad51 potentiation by Rad51 paralogs. To achieve this, we will employ an interdisciplinary approach combining structural biology, biophysics, biochemistry, and genetics. This proposal is particularly well-placed to deliver novel insights because the historical obstacle in the analysis of Rad51 paralogs—the native purification of functional protein of sufficient yield and quantity—has already been overcome by the Researcher. Furthermore, the Supervisor has extensive expertise in cryo-electron microscopy, which is now a viable approach to visualise the finer structural features of proteins that have been recalcitrant to classical techniques such as X-ray crystallography. Thus, by uniting the experiences of the Researcher and Supervisor, this fellowship has the potential to answer long-standing and significant questions in the field of HR. In addition to maintaining genome stability, HR plays critical roles in gametogenesis, chromosomal biology, and evolution. If awarded, this proposal therefore has the potential to impact several disciplines within the life sciences, and this is especially true given the interdisciplinary nature of the proposed research.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores