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STEM CELL PLASTICITY IN ADULT NEUROGENIC NICHES

Somatic stem cells (SCs) sustain tissue renewal and regeneration in adult mammals. The maintenance of their stemness and long-lasting preservation in cohabitation with differentiated progeny at specific niches poses these cells to... see more

30/11/2028

2M€

Project Budget: 2M€

Project leader

UNIVERSITAT DE VALÈNCIA (ESTUDI GENERAL) No se ha especificado una descripción o un objeto social para esta compañía.

without technological profile

PARTICIPATION DEPralty Sin fecha límite de participación.

Financing granted El organismo HORIZON EUROPE notifico la concesión del proyecto The day 2023-09-05

ERC-2022-ADG: ERC ADVANCED GRANTS Scope:Objectives

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

2.50M€ | Leader

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Project duration: 62 months Date Start: 2023-09-05
End date: 2028-11-30

Project leader

UNIVERSITAT DE VALÈNCIA (ESTUDI GENERAL) No se ha especificado una descripción o un objeto social para esta compañía.

without technological profile

Project Budget 2M€

participation deadline Sin fecha límite de participación.

Project description Somatic stem cells (SCs) sustain tissue renewal and regeneration in adult mammals. The maintenance of their stemness and long-lasting preservation in cohabitation with differentiated progeny at specific niches poses these cells to a considerable challenge. To deal with it, SCs display a complex network of yet to be fully uncovered mechanisms that allow multilevel plasticity. Cellular plasticity indicates the ability of cells to reversibly change their phenotype in response to the microenvironment. In the subependymal zone of the adult rodent brain, self-renewing neural SCs (NSCs) generate new neurons for pre-existing olfactory circuits. It is clear that NSCs must be endowed with plasticity properties, but the analysis of these potential traits needs a precise definition and a combination of comprehensive approaches to unravel their molecular regulation. Building from our new technologies and some preliminary data, in this proposal we will try to advance in the molecular basis and extent of the cell plasticity repertoire of adult subependymal NSCs by concentrating in three of its potential forms: Epithelial plasticity, or the ability to dynamically and reversibly undergo epithelial-to-mesenchymal transitions, a form of cell adaptation that has never been conceptually proposed or evaluated in adult NSCs. Cycling plasticity, or the ability to move in and out of the cell cycle and remain quiescent for long periods of time. This plasticity clearly exists, but its molecular regulation remains largely elusive. Immune plasticity, or the capacity to evade adaptive immunity. Our view about immunity in the brain has dramatically changed in the last few years, raising interest in its potential interaction with NSCs. Understanding cell plasticity traits in NSCs may contribute to understand not only NSC and/or SC behavior, but also glioma biology and to identify pathways to intervene in brain tumor treatment.

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