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Stability and transition in extracorporeal blood flow devices: understanding flo...

Stability and transition in extracorporeal blood flow devices: understanding flow-induced hemolysis and thrombogenesis The blood flow in extracorporeal medical devices is exposed to non-physiological conditions, which may lead to red blood cell damage and clot formation. Several therapies are applied to patients to prevent these phenomena, but the... ver más

31/08/2027

GSSI

189K€

Presupuesto del proyecto: 189K€

Líder del proyecto

GRAN SASSO SCIENCE INSTITUTE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-04-23

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023 ExpectedOutcome:Project results are expected to contribute to the following outcomes:

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No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

GSSI

188.59K€ | Lider

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Duración del proyecto: 40 meses Fecha Inicio: 2024-04-23
Fecha Fin: 2027-08-31

Líder del proyecto

GRAN SASSO SCIENCE INSTITUTE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 189K€

Descripción del proyecto The blood flow in extracorporeal medical devices is exposed to non-physiological conditions, which may lead to red blood cell damage and clot formation. Several therapies are applied to patients to prevent these phenomena, but they all come with side effects. Understanding the causes of flow-induced hemolysis and thrombogenesis would reduce the need for medical therapies, thus enhancing the well-being of the patients. An extracorporeal membrane oxygenation (ECMO) circuit is made up of several components: a blood pump, a membrane oxygenator, cannulae, tubes and connectors. The blood flow through these components is either turbulent or transitional, thus the blood is subject to hydrodynamic stresses that may lead to hemolysis or platelet activation. The link of these two undesired phenomena with the flow regimes and the transition mechanism has not been investigated in previous studies, and it is the aim of the current project. We will perform high-fidelity, three-dimensional numerical simulations of the flow in the connectors and the curved flexible tubes of an ECMO circuit. A non-Newtonian rheological model will be assumed for the blood viscosity. Transition to turbulence will be studied employing both modal and non-modal three-dimensional global stability analysis. For this purpose, a time-stepping technique will be implemented in the numerical code developed by the host's group, combined with a method for solving large-scale eigenvalue problems. Finally, an adjoint sensitivity analysis of the hemolysis index and the platelet activation state to boundary conditions and modifications in the flow will be performed. These results will provide insightful information for the design of medical devices with increased hemodynamic performance.

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