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SPECCC

Financiado

Cerrado

Specialised Cell Carrier Components

Silicone offers significant advantages as a 3D cell scaffold, essentially a 3D microtissue device. These benefits include a capacity for variable porosity, variable open pore volume for cell entrapment, variable density for fluid... ver más

31/10/2020

Cellon

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

CELLON SA No se ha especificado una descripción o un objeto social para esta compañía.

Fecha límite participación Sin fecha límite de participación.

Ver 6 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2020-10-31 No tenemos la información de la convocatoria

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

6 Participantes

Cellon

416.47K€ | Lider

IBET

4.87K€ | Participante

UNIVERSITY OF LIMERICK

2.40K€ | Participante

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Líder del proyecto

CELLON SA No se ha especificado una descripción o un objeto social para esta compañía.

Presupuesto del proyecto 1M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Silicone offers significant advantages as a 3D cell scaffold, essentially a 3D microtissue device. These benefits include a capacity for variable porosity, variable open pore volume for cell entrapment, variable density for fluidisation, variable geometry, friction resistance, and low toxicity. The lead SME partner Cellon SA holds the IP for porous silicone carriers (Immobasil), which met some of these criteria, but exhibited poor cell adherence and requires re-engineering and exploitation of current cell biology knowledge and applications. There is a strong commercial need for such fully functional 3D cell culture technologies (microtissue) that can be manufactured into robust and reproducible in vitro test systems for toxicity testing, drug testing, cosmetic testing as part of a projected €1.6b cell based test market. This technology developed maybe suitable as an active component in bioartificial livers (BAL) and other bioartificial organ devices. The market growth is driven by needs in drug screening for drug discovery and toxicity screening. There are also a number of current EU directives that is driving the demand for reliable in vitro 3D cell based test system to replace in vivo test systems. The bio artificial liver market is also expected to grow rapidly due to high rates of liver disease worldwide. The objectives will be to deliver: 1) Immortalised hepatocyte and endothelial cells that retain characteristics of primary liver cells in 3D co-culture. 2) An improved porous silicone carrier for 3D culture of these cells (cell-carrier component) 3) A prototype fluidized bioreactor bed for culture of these cell carrier components. 4) Cell carrier component tested in a microwell plate The results of this project could form the basis for subsequent (following the completion of the SpeCCC project) commercial development as follows 1) 3D liver cell multiwell plate assay system, 2) 3D liver microbioreactor system and 3) a bioreactor component for a BAL device. Minimal SME economic return is predicted at €12m within 3 years of project completion.

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