SESAHME
Financiado
Spatially rEsolved Single-cell Approaches in Haematologic MalignanciEs
A global understanding of therapy response and therapy resistance in haematologic malignancies, including multiple myeloma and acute lymphoblastic leukaemia, in which cancerous cells accumulate in the bone marrow, is still lacking...
A global understanding of therapy response and therapy resistance in haematologic malignancies, including multiple myeloma and acute lymphoblastic leukaemia, in which cancerous cells accumulate in the bone marrow, is still lacking. This is due to the complex nature of the bone marrow. Therefore, the goal of SESAHME is to determine the difference of the bone marrow microenvironment in healthy individuals and patients suffering from multiple myeloma and acute lymphoblastic leukaemia. This will help to understand under which conditions cancerous cells can accumulate and proliferate in the bone marrow which could lead to advanced immunotherapy approaches in the future.
To achieve this, the objectives of SESAHME are to 1) establish a method that allows to determine the immune microenvironment composition in human formalin-fixed paraffin-embedded samples of the bone marrow, which has the potential for high-throughput screening and being cost effective at the same time; and 2) to use this method to characterise a healthy and dysfunctional bone marrow microenvironment that can contribute to multiple myeloma/acute lymphoblastic leukaemia development and progression.
SESAHME will allow the fellow to independently carry out a project which will set the ground to build upon an own, individual research profile to eventually become an independent researcher. Key transferable training will further improve the employability and career prospects of the fellow, as well as increase the fellow’s communication abilities. The host offers a multi-disciplinary environment that is well connected with experts in the field enabling the fellow to develop a new mindset and approaches. The fellow brings international and specialised wet-lab experience that will facilitate knowledge exchange and increase R&I capacity. Finally, SESAHME will increase the global attractiveness of the host via concrete dissemination activities.
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Duración del proyecto: 24 meses
Fecha Inicio: 2022-08-01
Fecha Fin: 2024-08-31
Fecha Fin: 2024-08-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-08-31
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-MSCA-2021-PF-01-01:
MSCA Postdoctoral Fellowships 2021
Cerrada
hace 3 años
Presupuesto
El presupuesto total del proyecto asciende a
174K€
Líder del proyecto
UNIVERSITATSKLINIKUM HEIDELBERG
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5