STOPAPCG1IMP
Financiado
Spatial temporal regulation of APC C its role on G1 arrest and impact on termin...
Spatial temporal regulation of APC C its role on G1 arrest and impact on terminal differentiation
Coupling the cell-autonomous process of the cell cycle with spatiotemporal clues that promote the differentiation process is a major challenge in developmental biology. The retina aberrant in pattern (rap) gene was initially ident...
Coupling the cell-autonomous process of the cell cycle with spatiotemporal clues that promote the differentiation process is a major challenge in developmental biology. The retina aberrant in pattern (rap) gene was initially identified as a retina differentiation and patterning gene in Drosophila. It was later discovered to encode Fizzy-related (Fzr), a coactivator of the cell cycle regulator, Anaphase Promoting Complex/Cyclosome (APC/C). This was a critical initial step towards establishing a link between differentiation and cell cycle regulation. This project aims to understand the coordination between mechanisms of proliferation and differentiation, with a particular focus on the APC/C complex. The requirement of individual APC/C components to sustain the developmentally controlled G1 arrest and its subsequent effects on terminal differentiation will be addressed. The transcriptional and posttranslational regulation of each APC/C component will be assayed during eye development. Next, functional APC/C interactors will be identified through two complementary screens. An in vivo gain-of-function overexpresion screen will be performed, to identify the genes that can induce cell cycle arrest in overproliferating tissues, using the newly developed FlyORF library. Additionally, a proteomic analysis of APC/C components will be performed to identify eye-specific APC/C interactors. With the information gained I will investigate how the activity and expression of the APC/C is spatial-temporally controlled by signalling cascades during eye development, and how the APC/C in turn modulates the activation and output of those signalling pathways. Overall, the insights from this project will contribute to our understanding of complex diseases such as cancer and neurodegeneration.
ver más
Duración del proyecto: 29 meses
Fecha Inicio: 2015-03-25
Fecha Fin: 2017-08-31
Fecha Fin: 2017-08-31
Línea de financiación: concedida
El organismo H2020 notifico la concesión del proyecto el día 2017-08-31
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
MSCA-IF-2014-EF:
Marie Skłodowska-Curie Individual Fellowships (IF-EF)
Cerrada
hace 10 años
Presupuesto
El presupuesto total del proyecto asciende a
195K€
Líder del proyecto
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN...
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5
276.64K€ |
Participante