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INTERACTINGMICROBES

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Social Interactions in Microbes

Modern cell biology rests upon the power of studying pure cultures, often in shaking flasks. However, in nature cell groups are complex systems that frequently contain genetically-distinct populations. This genetic diversity range... ver más

30/09/2016

UOXF

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

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Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2016-09-30 No tenemos la información de la convocatoria

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Líder del proyecto

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Modern cell biology rests upon the power of studying pure cultures, often in shaking flasks. However, in nature cell groups are complex systems that frequently contain genetically-distinct populations. This genetic diversity ranges from point mutations that separate normal and cancerous tissue, through different strains of malaria in a host, to bacterial biofilms that contain a myriad of species. My research focuses on how genetic variability affects and explains the biology of cell groups, using microbes as a model system. The presence of different genotypes in a cell group leads to the potential for strong interactions. It is not sufficient, therefore, to study single genotypes alone; we need a systems biology of cell groups. Towards this aim, we combine the theories of social evolution and collective behaviour with the empirical study of microbes in two main approaches. The first focuses on the effects of mutation-driven diversity on a key bacterial trait - polymer secretion - that is central to bacterial life. The second approach focuses on the genetic diversity that arises when strains and species mix together. Here, we are developing a set of assays to investigate the effects of strain and species mixing centred upon Pseudomonas aeruginosa; a pathogenic bacterium that forms biofilms in the cystic fibrosis lung. We combine biofilm assays with transcriptomics to characterize the mechanisms that allow P. aeruginosa to invade environments containing benign species that might otherwise afford protection to a host. By taking a stepwise strategy that systematically adds back components of the physical and social environment, we aim to break down the daunting complexity of natural microbe communities. The ultimate goal is to build a predictive framework that goes from the mechanisms of social interaction among cells up to the emergent properties of natural communities.

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