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SMOC2 in osteoarthritis

"This project will study the role of SMOC2 in the biology and pathology of synovial joints with specific attention towards osteoarthritis (OA), one of the most common chronic diseases. SMOC2 is a novel secreted protein that can in... ver más

30/04/2014

KU Leuven

170K€

Presupuesto del proyecto: 170K€

Líder del proyecto

KATHOLIEKE UNIVERSITEIT LEUVEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2014-04-30 No tenemos la información de la convocatoria

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

KU Leuven

0.00€ | Lider

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Líder del proyecto

KATHOLIEKE UNIVERSITEIT LEUVEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 170K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto "This project will study the role of SMOC2 in the biology and pathology of synovial joints with specific attention towards osteoarthritis (OA), one of the most common chronic diseases. SMOC2 is a novel secreted protein that can interact with bone morphogenetic protein (BMP) and Wingless-like (Wnt) signaling key pathways in joint development, homeostasis, disease and repair. We will use a translational research approach combining in vitro data with mechanistic insights obtained in a well characterized animal model and then linking this to ex vivo patient data. In addition, SMOC2 and modified versions of the protein will be specifically tested for therapeutic applications. If successful, this project will teach us how SMOC2 interacts with BMP and Wnts in joint biology and disease. The aim is to define SMOC2 biology as a therapeutic target to improve diagnosis, treatment and prognosis of osteoarthritis. Dr. Cailotto, the experience researcher candidate for the fellowship, will be trained in the use of animal models and dealing with translational research hypotheses. He will also benefit from complementary skills training and interactions with industry in order to gain further maturity and independence as a researcher. This additional training will be beneficial to his career as well as to the European Research Area as there is a great societal need for translational researcher in the field of chronic joint diseases able to make links between basic biology and clinical questions. The project pays specific attention to cross-sectorial interactions and communication with the scientific community as well as with the primary stakeholders for osteoarthritis: the patients and population at risk."

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