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BUCKLING BRIDGES

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Smart wavy patterned implants with instructive properties for tissue regeneratio...

Smart wavy patterned implants with instructive properties for tissue regeneration by controlling the degree of fibers buckling. In the pursuit for engineering CELL HYBRIDGE regenerative medicine implants able to regenerate skeletal tissues by controlling adult stem cell activity, we have developed an innovative method to successfully improve cell migration... ver más

31/12/2019

UNIVERSITEIT MAAST...

150K€

Presupuesto del proyecto: 150K€

Líder del proyecto

UNIVERSITEIT MAASTRICHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-12-31

ERC-2017-PoC: ERC-Proof of Concept

I+D

Cerrada hace 7 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

UNIVERSITEIT MAASTRICHT

150.00K€ | Lider

REMOSA

228.72K€ | Participante

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Duración del proyecto: 24 meses Fecha Inicio: 2017-12-08
Fecha Fin: 2019-12-31

Líder del proyecto

UNIVERSITEIT MAASTRICHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 150K€

Descripción del proyecto In the pursuit for engineering CELL HYBRIDGE regenerative medicine implants able to regenerate skeletal tissues by controlling adult stem cell activity, we have developed an innovative method to successfully improve cell migration into electrospun scaffolds. Whereas this has a direct impact in CELL HYBRIDGE as part of the planned activities, we unexpectedly discovered that the same scaffolds display wavy patterns that have a direct influence on cell differentiation by enhancing their intrinsic capacity to produce growth factors. Driven by these observations, we have optimized the methodology and are able today to control the formation of such wavy patterns at a single fiber as well as multiple fiber scales by controlling the degree of buckling that the fibers are exposed to during processing. In doing so, we can reproduce the same waviness that is observed in several native tissues, among which tendons and ligaments. The aim of BUCKLING BRIDGES is to further investigate these instructive scaffolds as potentially smart implants for the regeneration of anterior cruciate ligaments. This will be done by further confirming our in vitro data and proof our concept by showing successful ligament regeneration in a preclinical animal model. While doing so, we will also explore the market potential of such products and develop a business plan for the creation of a spin-off company: TISSUE BRICKS.

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