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SYNERGIES

Financiado

Smart bioreactor-based platform for the multi-phYsical stimulatioN of Engineered...

Smart bioreactor-based platform for the multi-phYsical stimulatioN of Engineered osteochondRal tissues towards functional reGeneratIon and advanced diseasE modelS The incidence and socioeconomic burden of osteochondral (OC) diseases are growing worldwide, representing a major challenge for the healthcare systems. Tissue Engineering (TE) emerged as a promising alternative to the current inef... ver más

15/05/2026

POLITO

189K€

Presupuesto del proyecto: 189K€

Líder del proyecto

POLITECNICO DI TORINO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

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Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-04-11

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023 ExpectedOutcome:Project results are expected to contribute to the following outcomes:

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2 Participantes

POLITO

188.59K€ | Lider

7HC SOCIETA A RESPONSABILITA...

N.D. | Participante

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Duración del proyecto: 25 meses Fecha Inicio: 2024-04-11
Fecha Fin: 2026-05-15

Líder del proyecto

POLITECNICO DI TORINO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 189K€

Descripción del proyecto The incidence and socioeconomic burden of osteochondral (OC) diseases are growing worldwide, representing a major challenge for the healthcare systems. Tissue Engineering (TE) emerged as a promising alternative to the current ineffective OC disease treatments. However, state-of-the-art OCTE strategies are still unable to create functional engineered tissues, mainly due to their inability to replicate in vitro the complex physicochemical environment of the native OC tissue within the articular joint, making OC regeneration a critical unmet medical need. The ambitious purpose of the SYNERGIES project is to fill this gap by developing a pioneering smart biomimetic bioreactor-based platform able to culture OC constructs under physiologically and clinically relevant multi-physical stimulations in a controlled and adaptive manner. Cutting-edge in silico modelling and machine learning (ML) tools will be employed for the operational parameters optimization and for the smart automated control of the bioreactor platform, respectively. The SYNERGIES platform will enhance the knowledge of OC tissue mechanobiology beyond the state-of-the-art and guide the improvement of protocols for the production of functional OC substitutes, which will be suitable in vitro models for OC disease research and drug screening, paving the way for new effective therapies. The proposed Fellowship will enable a highly interdisciplinary collaboration between myself, a talented post-doc with a strong track record on biomaterial scaffolds for OCTE, and the supervisors, leading experts on bioreactor engineering and in silico modelling/ML tools. The excellent working conditions at Politecnico di Torino and 7HC will promote my professional development, offering me new scientific expertise and leadership skills, significantly widening my career perspectives. Ultimately, SYNERGIES outcomes will be of remarkable benefit to the European biomedical sector, contributing to EU excellence and quality of life.

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