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Small open reading frames smORF as novel modulators of disorders of dietary ex...

Small open reading frames smORF as novel modulators of disorders of dietary excess Dietary excess is the major origin of cardiovascular diseases and remains the leading cause of mortality. Due to difficulties with bioinformatics detection and experimental analysis, along with their sheer numbers, small open read... ver más

05/09/2021

IMDEA ALIMENTACIÓN

257K€

Presupuesto del proyecto: 257K€

Líder del proyecto

IMDEA ALIMENTACIÓN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 260K€

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-09-05

MSCA-IF-2016: Individual Fellowships Objective:The goal of the Individual Fellowships is to enhance the creative and innovative potential...

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3 Participantes

IMDEA ALIMENTACIÓN

257.19K€ | Lider

THE SALK INSTITUTE FOR BIOLO...

SALK INSTITUTE

172.13K€ | Participante

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Duración del proyecto: 53 meses Fecha Inicio: 2017-03-17
Fecha Fin: 2021-09-05

Líder del proyecto

IMDEA ALIMENTACIÓN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 260K€

Presupuesto del proyecto 257K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Dietary excess is the major origin of cardiovascular diseases and remains the leading cause of mortality. Due to difficulties with bioinformatics detection and experimental analysis, along with their sheer numbers, small open reading frames (smORF) –of fewer than 100 amino acids– have been largely disregarded. Advances in bioinformatics, RNA-sequencing (ribosome profiling), biochemical (peptidomics) and functional (genetic) screens, suggest that a large amount of smORF are transcribed and sometimes widely conserved. However, how much of these smORF-encoded peptides or small proteins (microproteins (MPs)) are translated into a functional peptide is largely unknown. Moreover, whether food bioactive components modulate the expression of MPs remains complete obscure. Thus, the main goal of this project is to search for MPs that regulate lipid metabolism in the intestine in response to dietary excess. The intellectual merits of this proposal are threefold. First, it will use cutting-edge technology to search for novel functional MPs. Second, it will address a new group of novel potential players not previously addressed in lipid metabolism, providing a novel insight into disease mechanism and innovative therapeutic strategies. Last, by testing two common food bioactive components from our healthy Mediterranean diet, we will open up a completely new field of research in the area of nutrition and health. The research approach will involve (i) a genome-wide peptidomic screen and ribosome profiling analysis of lipid-induced intestinal MPs, (ii) the use of in vivo and in vitro biochemical approximations to validate the function of the selected intestinal peptide, and (iii) the use of dietary components hydroxytyrosol and the omega-3 polyunsaturated fatty acid DHA as proof of concept that MPs can be modulated by our diet food bioactive. This project is framed in the Food & Healthy Diet and Biotechnology research area in the European Union's Framework Programme HORIZON 2020

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