SUPD
Financiado
Sizing Up PD Cavity enhanced Characterisation of Single Biomarkers in Human Bio...
Parkinson’s disease is the most common movement disorder caused by neurodegeneration, for which there is no cure, no way of modifying the disease and no clinically accepted diagnostic tool. In the brain, the intrinsically disorder...
Parkinson’s disease is the most common movement disorder caused by neurodegeneration, for which there is no cure, no way of modifying the disease and no clinically accepted diagnostic tool. In the brain, the intrinsically disordered monomeric protein α-synuclein misfolds, aggregates and accumulates to form proteinaceous inclusions termed Lewy bodies. This process forms ‘oligomers’, intermediates in the aggregation pathway that are strongly implicated in the cellular toxicity that causes the disease. Oligomers are exceedingly challenging to study with traditional biophysical techniques because of their low abundance and variability in size, structure and stability. My research proposal aims to develop a new method capable of measuring the size and structural properties of single oligomers in human cerebral spinal fluid. By employing technologies in the field of cavity-enhanced spectroscopy and combining these with existing tools in single-molecule fluorescence I will investigate how the properties of oligomers in cerebral spinal fluid differ between healthy and Parkinson’s disease patients. In order to determine the molecular origins of Parkinson’s disease we need a comprehensive understanding of these pathogenic species. Achieving this goal will enable us to develop an early diagnostic tool which in turn will generate opportunities for therapeutic intervention.
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Duración del proyecto: 58 meses
Fecha Inicio: 2020-03-10
Fecha Fin: 2025-01-23
Fecha Fin: 2025-01-23
Línea de financiación: concedida
El organismo H2020 notifico la concesión del proyecto el día 2020-03-10
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
MSCA-IF-2019:
Individual Fellowships
Cerrada
hace 5 años
Presupuesto
El presupuesto total del proyecto asciende a
290K€
Líder del proyecto
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN...
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Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5
244.99K€ |
Participante