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SIRIUS

Financiado

Cerrado

Simulations for Inertial Particle Microfluidics

Cancer and bacterial infections are projected to kill 18 million people worldwide annually by 2050. Fast and reliable diagnostics are essential for early and targeted treatments. Microfluidics is at the heart of the miniaturisatio... ver más

30/09/2024

UEDIN

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

THE UNIVERSITY OF EDINBURGH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2024-09-30

ERC-2018-STG: ERC Starting Grant

I+D

Cerrada hace 7 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

UEDIN

1.50M€ | Lider

LABIANA LIFE SCIENCES

528.87K€ | Participante

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Duración del proyecto: 72 meses Fecha Inicio: 2018-09-04
Fecha Fin: 2024-09-30

Líder del proyecto

THE UNIVERSITY OF EDINBURGH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 1M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Cancer and bacterial infections are projected to kill 18 million people worldwide annually by 2050. Fast and reliable diagnostics are essential for early and targeted treatments. Microfluidics is at the heart of the miniaturisation of diagnostics, enabling novel portable and low-cost point-of-care devices. Inertial particle microfluidics (IPMF) is a novel and competitive method with applications in cancer cell and bacteria separation. Yet, the physics behind IPMF is not well understood, making progress slow and costly. Novel design rules are in urgent need to avoid trial-and-error experiments. I will numerically investigate the underlying physical mechanisms and develop the first predictive toolkit for engineering applications of IPMF. In particular, I will address five ambitious challenges in SIRIUS: 1. Develop an accurate numerical model for IPMF. 2. Understand the impact of particle softness. 3. Investigate the effect of finite particle concentration. 4. Improve the currently low separation efficiency of small particles. 5. Develop a toolkit to enable simulation-driven design. These objectives are feasible through novel numerical approaches based on the lattice-Boltzmann method and state-of-the-art high-performance computing. SIRIUS will pursue an innovative simulation campaign, validated with existing experimental data, to generate both physical insight and scaling laws for simulation-driven design. For the first time, SIRIUS will produce robust numerical methods for IPMF. My pioneering research will uncover the physics behind particle separation and culminate in a design toolkit for IPMF engineers. SIRIUS will fill a critical gap and open up an entirely new research field: Simulations for inertial particle microfluidics. Results of SIRIUS will be published as open-source codes, open-access articles, and open data. This will ultimately enable faster, less costly and more innovative research in the field of microfluidics for diagnostics.

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