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ARIADNE

Financiado

Cerrado

Signaling circuitry controlling fungal virulence identification and characteriz...

Signaling circuitry controlling fungal virulence identification and characterization of conserved and specific fungal virulence genes as common antifungal targets Fungi are heterotrophic microorganisms with devastating impact on agriculture and human health. Agricultural production worth billions of € is destroyed annually by fungal diseases. Human fungal infections have severe consequences... ver más

31/05/2014

CARLSBERG AS

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

CARLSBERG AS No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 9 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2014-05-31 No tenemos la información de la convocatoria

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Información adicional privada

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9 Participantes

CARLSBERG AS

0.00€ | Lider

MPG

N.D. | Participante

INRAE

N.D. | Participante

CSIC

N.D. | Participante

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Líder del proyecto

CARLSBERG AS No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Fungi are heterotrophic microorganisms with devastating impact on agriculture and human health. Agricultural production worth billions of € is destroyed annually by fungal diseases. Human fungal infections have severe consequences on the growing number of immuno-compromised patients, with high mortality rates associated with Aspergillus and Candida infections. There is a critical need to further the development of new antifungals, which requires a comprehensive molecular knowledge on fungal pathogenesis and signal transduction. ARIADNE uses a comparative biological approach at the systems biology level to identify and validate signalling target genes that play an essential causative role in fungal virulence on both plant and human hosts. To establish a comprehensive view of fungal pathogenesis seven pathogenic species will be studied, including the two major fungal pathogens of humans Aspergillus fumigatus and Candida albicans, the devastating plant pathogens Fusarium oxysporum, Magnaporthe grisea and Mycospherella graminicola, as well as two established model pathogens of filamentous and dimorphic fungi, Ashbya gossypii and Ustilago maydis. This array of fungal species cuts across diverse taxonomic groups, covering several hundred million years of evolution. The central scientific and technological challenges for ARIADNE are to 1) integrate parallel transcriptomics, proteomics, and chemical genetics for a comprehensive set of major fungal pathogens, 2) identify evolutionarily conserved and species specific signalling effectors which act as key players in fungal virulence, 3) validate these proteins as candidate targets for small molecule inhibitors. This groundbreaking scientific and teaching approach will open up new avenues on how to look at fungal pathogenicity and will generate an unprecedented knowledge platform, which will facilitate the discovery and validation of antifungal targets in both the agricultural and the pharmaceutical sectors.

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