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Sensing and Signalling in the Innate Immune Response using Drosophila as a Mode...

Sensing and Signalling in the Innate Immune Response using Drosophila as a Model The project seeks to advance our knowledge of the innate immune system at two different but complementary levels, sensing and regulation of signalling. The first aim is centred on danger signals, and how they activate the immune s... ver más

28/02/2015

CNRS

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-02-28 No tenemos la información de la convocatoria

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

CNRS

0.00€ | Lider

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Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The project seeks to advance our knowledge of the innate immune system at two different but complementary levels, sensing and regulation of signalling. The first aim is centred on danger signals, and how they activate the immune system. We propose to use high-throughput RNA sequencing, molecular biology, fly and bacterial genetics to investigate the global network of genes and pathways that are involved in either endogenous (DNA and chromatin components) or exogenous (pathogen virulence factors) danger signal sensing. Drosophila is used here as a model system to analyse the complexities of host-pathogen interactions. As many bacteria use a common set of virulence factors to target different hosts, this work should lead to the identification of new defence genes and mechanisms in human. The second aim seeks to understand the mechanisms that fine-tune NF-ºB signalling in Drosophila and in mammals. NF-ºB mediates every aspect of inflammation and immune response through transcriptional programs that have to be orchestrated by yet unknown regulatory layers. The ability to effectively target inflammatory diseases for therapeutic intervention requires knowledge of the intricacies of these regulatory layers. First, we propose to characterize the molecular function of a new modulator of NF-ºB signalling that we have recently discovered, by using yeast two-hybrid screens, mass spectrometry and Drosophila genetics. In parallel, we propose to analyze the role of newly discovered and evolutionary conserved small RNAs in the regulation of the innate immune response in Drosophila. This exciting new area of research should lead to a better understanding of the control of immune reactions, one of the most important goals for medical research in the next decade.

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