SMART
Financiado
Self-Monitoring of Prostate cancer by Automated hybrid Recognition of Exosomal m...
Self-Monitoring of Prostate cancer by Automated hybrid Recognition of Exosomal miRNA: toward personalized analytical Tool
"Tumor-derived circulating exosomes are a suitable, readily accessible reservoir of cancer biomarkers for disease process analysis. The microRNAs (miRNAs) inside the exosomes provide information about the mechanisms of change in c...
"Tumor-derived circulating exosomes are a suitable, readily accessible reservoir of cancer biomarkers for disease process analysis. The microRNAs (miRNAs) inside the exosomes provide information about the mechanisms of change in cancer of affected individuals. Quantitative determination of miRNAs in the exosome, a clinical area of unmet need, is tempting but challenging. The main objectives of the proposal are to develop a non-invasive, affordable, user-friendly, and deliverable platform that can measure mutant miRNA-107 in prostate cancer (PCa)-associated exosomes with unmatched accuracy, combining a hybrid oligonucleotides (ONs)-nanomaterials integrated composite system with an E-μPAD. The proposed platform offers ""Self-Monitoring of Prostate Cancer by Automated hybrid Recognition of Exosomal miRNA: towards personalized analytical Tool"" named "" SMART"". SMART provides a universal technology for non-invasive PCa diagnosis and quantitative tracking of miRNA levels in cancer-derived exosomes in a very simple and effortless manner in biofluids such as serum and urine. The novelty of the proposed interdisciplinary project work will evolve into the next generation of intelligent point-of-care (POC) tools for precision medicine. This proposal will contribute to the sustainability of the healthcare system by enabling patients to stratify and/or predict disease, thereby improving clinical decision making. This MSCA PF will be carried out at the University of Naples, Italy, will provide the researcher with advanced technical training in exosome isolation, PCR and DNA sequencing, molecular biology, microfluidics, pathology, nanomaterials synthesis, analytical techniques, proposal and manuscript preparation, and academic supervision in research management. The proposed multidisciplinary collaboration in the SMART project has resulted in a new generation of smart medical devices with functions comparable to existing highly specialized hospital devices."
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Duración del proyecto: 32 meses
Fecha Inicio: 2023-07-10
Fecha Fin: 2026-03-31
Fecha Fin: 2026-03-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-07-10
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-MSCA-2022-PF-01-01:
MSCA Postdoctoral Fellowships 2022
Cerrada
hace 2 años
Presupuesto
El presupuesto total del proyecto asciende a
173K€
Líder del proyecto
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5