Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

SELFORGANICELL

Financiado

Self Organization of the Bacterial Cell

One of the most remarkable features of biological systems is their ability to self-organize in space and time. Even a relatively simple cell like the bacterium Escherichia coli has a precisely regulated cellular anatomy, which eme... ver más

31/03/2021

IST AUSTRIA

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-03-31

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-StG-2015: ERC Starting Grant

I+D

Cerrada hace 9 años

0% 100%

2 Participantes

IST AUSTRIA

1.50M€ | Lider

SAINT-GOBAIN ABRASIVOS, S.A.

530.28K€ | Participante

Proyectos interesantes

BFU2010-21847-C02-02 ESTRUCTURA REDES Y MOTIVOS MOTIFS CELULARES 67K€ Cerrado

IJCI-2017-33497 Conserved mechanisms of cell organization among eukaryote 64K€ Cerrado

BES-2009-025690 COORDINACION ENTRE DIVISION Y DIFERENCIACION CELULAR EN ORGA... 43K€ Cerrado

EEBB-I-12-04051 COORDINACION ENTRE DIVISION Y DIFERENCIACION CELULAR EN ORGA... 5K€ Cerrado

PRE2020-094866 Estudio de los mecanismos moleculares y celulares que interv... 99K€ Cerrado

BFU2017-88202-P RELACIONES INTERCELULARES EN CIANOBACTERIAS MULTICELULARES Y... 169K€ Cerrado

Últimas noticias

30-11-2024: Cataluña Gestión For... Se ha cerrado la línea de ayuda pública: Gestión Forestal Sostenible para Inversiones Forestales Productivas para el organismo:

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

Duración del proyecto: 63 meses Fecha Inicio: 2015-12-10
Fecha Fin: 2021-03-31

Líder del proyecto

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA

TRL 4-5

Presupuesto del proyecto 1M€

Descripción del proyecto One of the most remarkable features of biological systems is their ability to self-organize in space and time. Even a relatively simple cell like the bacterium Escherichia coli has a precisely regulated cellular anatomy, which emerges from dynamic interactions between proteins and the cell membrane. Self-organization allows the cell to perform extremely challenging tasks. For example, for cell division, more than ten different proteins assemble into a complex, yet highly dynamic machine, which controls the invagination of the cell while constantly remodeling itself. Although the individual components involved have been largely identified, how they act together to accomplish this challenge is not understood. It has become clear that sophisticated biochemical networks give rise to intracellular organization, but we have yet to uncover the underlying mechanistic principles. In this research proposal, I aim to develop a detailed mechanistic understanding of the self-organizing, emergent properties of the cell. To this end, my research group will develop novel in vitro reconstitution experiments combined with high-resolution fluorescence microscopy and theoretical modeling. Following this bottom-up approach, we will quantitatively analyze collective protein dynamics and emergent mechanochemical properties of the bacterial cell division machinery. I aim to answer the following fundamental questions: 1) What is the biochemical network giving rise to the dynamic assembly of the divisome? 2) How do the components of the divisome interact to generate force? 3) How do peptidoglycan synthases build the cell wall? By comparing protein dynamics in vitro with those measured in vivo, we will provide a link between molecular properties and the processes found in the living cell. This project will not only improve our understanding of the bacterial cell, but also open new research avenues for eukaryotic cell biology, synthetic biology and biophysics.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores