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SAPHELY

Financiado

Cerrado

Self amplified photonic biosensing platform for microRNA based early diagnosis o...

Self amplified photonic biosensing platform for microRNA based early diagnosis of diseases The SAPHELY project focuses on the development and the preclinical validation of a nanophotonic-based handheld point-of-care (POC) analysis device for its application to the minimally-invasive early diagnosis of diseases, with a f... ver más

31/07/2018

UPV

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

UNIVERSITAT POLITÈCNICA DE VALÈNCIA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 688

Fecha límite participación Sin fecha límite de participación.

Ver 9 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2018-07-31

ICT-26-2014: Photonics KET Scope:Specific Challenge: Europe's photonics industry is facing fierce global market competition and...

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

9 Participantes

UPV

945.70K€ | Lider

UEA

323.51K€ | Participante

APR

370.08K€ | Participante

MICROTEC GESELLSCHAFT FUR MI...

226.25K€ | Participante

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Duración del proyecto: 43 meses Fecha Inicio: 2014-12-15
Fecha Fin: 2018-07-31

Líder del proyecto

UNIVERSITAT POLITÈCNICA DE VALÈNCIA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 688

Presupuesto del proyecto 3M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The SAPHELY project focuses on the development and the preclinical validation of a nanophotonic-based handheld point-of-care (POC) analysis device for its application to the minimally-invasive early diagnosis of diseases, with a focus in cancer. Disease identification will be based in the fast (<5 minutes), ultra-sensitive (sub-pM) and label-free detection of novel highly-specific microRNA (miRNA) biomarkers, using a small volume of whole blood (<100 μL). This POC analysis device, which will have a low cost (envisaged cost < €3000), will significantly help in the implementation of mass screening programs, with the consequent impact on clinical management, reducing also costs of treatments, and increasing survival rates. The ultra-high sensitivity required for the direct detection of miRNA biomarkers present in the bloodstream will be achieved by using a novel sensing amplification technique. This technique is based in the use of molecular beacon capture probes with an attached high index nanoparticle, so that the hybridization events are translated into the displacement of these nanoparticles from the sensor surface. The use of this self-amplification technique avoids the use of complex PCR-based amplification methods or labelling processes, which are difficult to implement on-chip. The cost, size and weight reduction required for deploying an affordable handheld POC device will be achieved by using a novel power-based readout scheme for photonic bandgap sensing structures where the use of expensive, bulky and heavy tuneable lasers and spectrometers is avoided. Special attention will be paid within the SAPHELY project to explore the potential deployment and commercialisation of the analysis device, by means of the involvement of relevant academic and industrial partners, as well as end users.

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