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SMARTBOX

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Selective Modifications of ARomatics through Biocatalytic Oxidations

Although they have the potential to improve the economic and environmental sustainability of biorefineries, oxidative enzymes have not experienced a complete breakthrough yet in the biobased industries. This is mainly caused by th... ver más

31/10/2023

BIOPILOT PLANT BBE...

5M€

Presupuesto del proyecto: 5M€

Líder del proyecto

BIO BASE EUROPE PILOT PLANT VZW No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-10-31

BBI.2018.SO2.R2: Develop techniques and systems to i... Specific Challenge:Biocatalysts – enzymes and the microorganisms that contain them – offer great pot...

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13 Participantes

BIOPILOT PLANT BBEPP

885.38K€ | Lider

AQUAMOBILE, S.L.

288.92K€ | Participante

ESTRENOS 21

277.34K€ | Participante

B4PLASTICS

180.40K€ | Participante

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Duración del proyecto: 54 meses Fecha Inicio: 2019-04-26
Fecha Fin: 2023-10-31

Líder del proyecto

BIO BASE EUROPE PILOT PLANT VZW No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 5M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Although they have the potential to improve the economic and environmental sustainability of biorefineries, oxidative enzymes have not experienced a complete breakthrough yet in the biobased industries. This is mainly caused by the high cost and long time associated with traditional enzyme engineering methods such as directed evolution. SMARTBOX will develop an advanced computational engineering platform specifically for oxidative enzymes, which can automatically screen for improved enzyme variants with minimal human intervention. This is achieved by implementing several innovations into current computational screening methods, most importantly machine learning, which allows to train the algorithms with experimental results. As this significantly improves computational predictability, the time and costs associated with oxidative enzyme engineering will be reduced 10-fold compared to state-of-the-art (SOTA) directed evolution methods. Relying on the advanced engineering platform, SMARTBOX will develop the one-enzyme conversion of HMF into FDCA and intermediates, and the one-enzyme conversion of lignin monomers into a potential biobased building block for polycarbonates and vanillin. By adopting a 1-enzyme FDCA production process, the associated production costs and carbon footprint are expected to decrease significantly compared to SOTA chemical oxidation methods. The unique feature of SMARTBOX is that reductive catalytic fractionation (RCF) will be used to selectively produce specific lignin monomers from biomass in near theoretical yields. The structural similarity of the resulting monomers with the SMARTBOX building blocks allows the development of high-yielding processes with only one enzyme. Due to the smart combination between oxidative biocatalysis and RCF, the production of bio-aromatics will proceed with higher yields than the state of the art.

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