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STRIM

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Scientific Training for Post Translational Modification Detection in Cancer Scre...

Scientific Training for Post Translational Modification Detection in Cancer Screening Cancer remains one of the greatest challenges to the EU healthcare systems. Early detection and diagnosis dramatically increases the prospect of successful treatment and survival. Academia and the rapidly growing cancer diagnostic... ver más

30/09/2028

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4M€

Presupuesto del proyecto: 4M€

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Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-06-28

HORIZON-MSCA-2023-DN-01-01: MSCA Doctoral Networks 2023 Expected Outcome:Project results are expected to contribute to the following outcomes:

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12 Participantes

KRAEFTENS BEKAEMPELSE

HELMHOLTZ-ZENTRUM DRESDEN-RO...

TECHNISCHE UNIVERSITAET DRES...

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Duración del proyecto: 51 meses Fecha Inicio: 2024-06-28
Fecha Fin: 2028-09-30

Líder del proyecto Líder desconocido

Presupuesto del proyecto 4M€

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Descripción del proyecto Cancer remains one of the greatest challenges to the EU healthcare systems. Early detection and diagnosis dramatically increases the prospect of successful treatment and survival. Academia and the rapidly growing cancer diagnostics and biosensors sectors have an urgent need for researchers skilled in developing improved screening technologies, which can offer major opportunities to impact cancer survival. However, the development of assays with the required sensitivity, reliability and technology formats for multi-cancer early detection is only recently emerging and faces significant R&D challenges. STRIM will train a cohort of researchers in the multi-disciplinary science, bioinformatics, technology, social, clinical and health-economic skills required to deliver comprehensive bioelectronic tools for cancer screening, tools that are fast, accurate, sensitive, and exploit advanced molecular receptors and nanobiotechnologies for detection of aberrant post-translational modifications (PTM) of proteins and nucleic acids as cutting-edge biofluid markers for early detection of cancers. Growing evidence suggests that PTM play important roles in human cancers and are likely to prove highly specific for cancer type. Focusing on both genomic and proteomic PTM biomarkers will be a game-changing strategy for improving early cancer detection rates, efficiency and population health. Doctoral training in STRIM will encompass state-of-the art approaches for ultra-sensitive detection of PTM biomarkers as cancer screening tools by building on recent advances in electrochemiluminescence, aptamer and DNA microarrays and conducting polymer micro-structured electrodes. These techniques will reach new levels of specificity and overcome barriers to the realization of multiplexed diagnostics for enhanced cancer screening. All translational issues will be considered in harmonization with regulatory and health technology assessment and social acceptability will be screened in the population.

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