Saturated bioisosteres of benzene and their application in drug design
More than 500 of all existing drugs are phenyl-containing organic molecules. During the recent years, however, pharmaceutical companies struggle to deliver novel drugs to the market, because of the lack of innovative practical app...
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Información proyecto BENOVELTY
Duración del proyecto: 63 meses
Fecha Inicio: 2020-12-14
Fecha Fin: 2026-03-31
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
More than 500 of all existing drugs are phenyl-containing organic molecules. During the recent years, however, pharmaceutical companies struggle to deliver novel drugs to the market, because of the lack of innovative practical approaches towards novel drug-like chemical space. In this project, we will address this issue by developing novel saturated bioisosteres for ortho- and meta-substituted benzenes, and incorporate them into several known drugs (intiinflamatory Aceclofenac, antiviral Tipranavir, antihypertensive Oxprenolol, etc) to provide novel patent-free analogues with improved physico-chemical and biological properties.