Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

DROPCOS

Financiado

Role of the neuroendocrine axis and its link with obesity in the genesis of PCOS

Polycystic ovary syndrome (PCOS) is a human hormonal disorder of complex etiology, characterized by reproductive, endocrine and metabolic abnormalities, which affects 15% of women of reproductive age and has a very low survival ra... ver más

30/04/2025

CSIC

181K€

Presupuesto del proyecto: 181K€

Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-14

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 ExpectedOutcome:

I+D

Cerrada hace 2 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

CSIC

181.15K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

GRASP Antagonizing GnRH signaling as a holistic therapeutic strate... 150K€ Cerrado

SAF2014-56995-JIN HIPOGONADISMO INDUCIDO POR SOBREPESO COMO PRINCIPAL FACTOR E... 204K€ Cerrado

INFISS Targeting infertility associated to defective Insulin IGF 1... 150K€ Cerrado

REPRODAMH Extra gonadal roles of Anti M llerian Hormone in the aetiolo... 2M€ Cerrado

PID2021-126915OA-I00 EXCESO DE ANDROGENOS E HIGADO GRASO ASOCIADO A DISFUNCION ME... 169K€ Cerrado

CPP2021-008338 ESTUDIO DE UNA NUEVA ESTRATEGIA TERAPÉUTICA PARA TRATAR EL S... 1K€ Cerrado

Duración del proyecto: 25 meses Fecha Inicio: 2023-03-14
Fecha Fin: 2025-04-30

Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Presupuesto del proyecto 181K€

Descripción del proyecto Polycystic ovary syndrome (PCOS) is a human hormonal disorder of complex etiology, characterized by reproductive, endocrine and metabolic abnormalities, which affects 15% of women of reproductive age and has a very low survival rate. Recent studies on its pathophysiology suggest that it reflects alterations in homeostatic feedback mechanisms between the ovaries, adipose tissue, and hypothalamic circuits that develop during embryogenesis. Despite its high prevalence and significant impact on health, there are no effective treatments for PCOS due to its complex etiology. The development of new animal models displaying features of human PCOS is an unmet need because classical mouse models of PCOS have relied on its induction with androgen excess, providing only very limited insight into the pathogenesis of PCOS. In a genetic screen against secretable and transmembrane proteins involved in tissue-to-tissue communication, the host lab has identified new genes that act as sensors of the amount of body fat in the larval prothoracic endocrine gland of Drosophila. This gland corresponds to the neurosecretory part of the mammalian hypothalamus and mutants in these genes are characterized by PCOS. The main objective of this proposal is to characterize how cell communication in the neuroendocrine-adipose tissue-ovary axis is responsible for the uncontrolled proliferation of gonadal germ cells. The underlying PCOS will be studied using single-cell genomic approaches, metabolomics, and genetic studies on the different elements that make up this axis. By elucidating the molecular/hormonal mechanisms involved in brain-adipose tissue-ovary communication in normal development and disease, I hope to better define the pathogenesis and development of targeted therapies against PCOS.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores