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ROLEPS

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Role of Extracellular Polymeric Substances EPS in the prevalence and resilienc...

Role of Extracellular Polymeric Substances EPS in the prevalence and resilience of Lotmaria passim Lotmaria passim is a trypanosomatid parasite of bees, highly prevalent in honeybee colonies, considered a major factor in colony loss. Yet, the molecular mechanisms it uses to survive both inside and outside its host are unknown.... see more

31/12/2025

UGR

165K€

Project Budget: 165K€

Project leader

UNIVERSIDAD DE GRANADA No se ha especificado una descripción o un objeto social para esta compañía.

total researchers 5532

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo HORIZON EUROPE notifico la concesión del proyecto The day 2023-07-26

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 Expected Outcome:

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

UGR

165.31K€ | Leader

INSTITUTO REGIONAL DE INVEST...

N.D. | participant

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Project duration: 29 months Date Start: 2023-07-26
End date: 2025-12-31

Project leader

UNIVERSIDAD DE GRANADA No se ha especificado una descripción o un objeto social para esta compañía.

total researchers 5532

Project Budget 165K€

participation deadline Sin fecha límite de participación.

Project description Lotmaria passim is a trypanosomatid parasite of bees, highly prevalent in honeybee colonies, considered a major factor in colony loss. Yet, the molecular mechanisms it uses to survive both inside and outside its host are unknown. Preliminary studies showed that L.passim secretes extracellular polymeric substances (EPS) and differentiates into surface attached colonies mimicking the mechanism of bacterial biofilm formation. EPS provides environmental resistance to changing and extreme physicochemical conditions (e.g. in bacteria). Thus, I hypothesise that EPS confers resistance to L.passim and have an active role in the bee gut. In ROLEPS I aim to explore the role of EPS secretion and the mechanisms of biofilm formation in the prevalence and resilience of L.passim chasing three objectives: i) study the response of L.passim biofilms to biotic and abiotic stressors, ii) identify the genes involved in EPS secretion and the developmental differentiation into biofilms using CRISPR/Cas9, and iii) explore the function of EPS in honey bee health. ROLEPS will be developed at the University of Granada (Spain), within the Biochemistry and Molecular Parasitology group lead by Prof. de Pablos, who has developed a protocol to isolate trypanosomatid strains from field isolates, optimized the isolation of the secretome of trypanosomatids and settled all the facilities for genetic engineering assays. A secondment is planned at the Centro de Investigación Apícola y Agroambiental (CIAPA) in Marchamalo (Spain), supervised by Dr. Higes, expert on bee health. ROLEPS is an innovative project as it will analyse for the first time the role of EPS and biofilms in a trypanosomatid parasite of bees, it will integrate genetic engineering in the field of bee parasitology and test parasite-secreting substances as protection against contaminants in bees. ROLEPS is fully achievable due to the easy handling of the model organisms. Thus, I expect ROLEPS has important repercussions in bee health.

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