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RobustHormoneTrans

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Robustness and specialization among hormone transporters Redundant and unique r...

Robustness and specialization among hormone transporters Redundant and unique roles "Plant growth and development is governed by finely tuned, highly regulated hormone gradients. Impressive progress has been made in understanding plant hormone signaling, but knowledge on the mechanisms underlying their precise lo... ver más

31/12/2023

TAU

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

TEL AVIV UNIVERSITY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-12-31

ERC-2017-STG: ERC Starting Grant Scope:Objectives

I+D

Cerrada hace 8 años

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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2 Participantes

TAU

1.50M€ | Lider

ASTURIANA DE LAMINADOS,

1.07M€ | Participante

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Duración del proyecto: 75 meses Fecha Inicio: 2017-09-07
Fecha Fin: 2023-12-31

Líder del proyecto

TEL AVIV UNIVERSITY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto "Plant growth and development is governed by finely tuned, highly regulated hormone gradients. Impressive progress has been made in understanding plant hormone signaling, but knowledge on the mechanisms underlying their precise localization at the tissue and subcellular levels is still very limited. We and others have recently identified the first bona fide GA transporters in plants as members of the NPF protein family. Proteins from the ABC family were shown to transport the CK, ABA, and auxin hormones. Although these studies suggested specialized functions for members of these large protein families, progress in understanding their level of specialization has been limited by the scarcity of loss-of-function phenotypes, masked by the highly redundant plant genome. The goal of this proposal is to reveal the robust and specialized function of the NPF and ABC plant hormone transporter families. The project places key technological challenges that require multi-disciplinary expertise to examine how plants balance redundancy and specialization to tightly regulate hormone localization. Broad and targeted transportome screens using multi-targeted artificial miRNAs and CRISPR technology in Arabidopsis and tomato, respectively, are designed to unveil novel plant hormone transporters, with an emphasis on subcellular localized transporters and the missing GA exporters. Specialization and robustness of candidate transporters will be evaluated by integrating in vitro transport assays with in vivo growth and development experiments. I believe that the proposed ""redundant-free"" populations will lead to new paradigms in plant genetics and would explain how gene families have developed robustness together with unique and diverse specialization. Importantly, our combined genetic and organelle-specific hormone profiling approaches will establish fundamental new concepts regarding plant hormone localization, activity, and specificity at the subcellular level."

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