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RISK-HUNT3R

Financiado

Cerrado

RISK assessment of chemicals integrating HUman centric Next generation Testing s...

RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs The vision of the RISK-HUNT3R consortium is to develop a reliable, efficient and cost-effective chemical safety assessment approach. It will be based entirely on non-animal methods and provide improved protection of the human popu... ver más

31/05/2026

ULEI

23M€

Presupuesto del proyecto: 23M€

Líder del proyecto

UNIVERSITEIT LEIDEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 39 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-01-22

SC1-BHC-11-2020: Advancing the safety assessment of...

I+D

Cerrada hace 4 años

0% 99% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

39 Participantes

ULEI

4.00M€ | Lider

ALHAMA LINARES DESARROLLO Y...

CHARLES RIVER LABORATOIRIES...

7.50K€ | Participante

Signatope

598.71K€ | Participante

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Duración del proyecto: 64 meses Fecha Inicio: 2021-01-22
Fecha Fin: 2026-05-31

Líder del proyecto

UNIVERSITEIT LEIDEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 23M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The vision of the RISK-HUNT3R consortium is to develop a reliable, efficient and cost-effective chemical safety assessment approach. It will be based entirely on non-animal methods and provide improved protection of the human population against systemic health effects caused by (chronic) chemical exposure. The major innovation provided by RISK-HUNT3R is a complete and truly human-centric risk assessment strategy. RISK-HUNT3R will establish, optimize and assemble all essential safety testing elements: exposure assessment, information on chemical distribution in the body, hazard characterization, adverse outcome prediction and determination of actual risk in defined scenarios. RISK-HUNT3R integrates cutting-edge in silico (computational) and in vitro (experimental testing) technologies. Human (disease) genetics and exposome data will ensure anchoring of test results to the human situation. The project will ensure regulatory relevance by testing the applicability of the critical test systems integrated in the next generation risk assessment strategy. The ambitious overall deliverable will be a comprehensive computational framework for the prediction of human adverse outcomes, and a set of stringently evaluated assays to feed the required data into this framework. RISK-HUNT3R will engage with all key stakeholders from different industry sectors and international regulatory agencies to critically evaluate and warrant genuine acceptance of the novel safety testing framework. This unique interaction of these key stakeholders working together on real-world case studies, will result in a ready-to-apply strategy to ensure societal protection against hazardous chemicals fully in concordance with the European Commission’s Green Deal. Importantly, the project will push commercial exploitation of the validated safety assessment approaches, thereby ensuring sustainability of the project outcomes and fortifying the innovation capacity of the industry sectors involved.

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