TROJAN
Financiado
Riding a Trojan horse against cancer
New therapeutic approaches have led to significant improvements in cancer treatment, but none have been able to overcome the limited efficacy of solid tumor treatment due to poor tumor delivery and the presence of hypoxic tumor ce...
New therapeutic approaches have led to significant improvements in cancer treatment, but none have been able to overcome the limited efficacy of solid tumor treatment due to poor tumor delivery and the presence of hypoxic tumor cells. Macrophages represent a promising vesicle to deliver cancer therapeutics to solid tumors as they are continuously recruited into the tumor mass, even the most hypoxic regions. Our pioneering research demonstrated that macrophages are able to take up ferritins loaded with anti-cancer drugs, creating Macrophage-Drug Conjugates (MDCs), and transfer these to cancer cells and kill them, a phenomenon we named TRAIN.
In my ongoing ERC STARTING GRANT PROJECT ‘MCHAP’, we have proven that MDCs can be used as a ‘Trojan horse’ to efficiently deliver drugs directly to the cancer cells via TRAIN.
Now we aim to turn the MDC technology into a COMMERCIAL and SOCIAL VALUE PROPOSITION by confirming our findings in a PDX model, which is crucial to raise interest of and establish a co-development (or licensing) deal with big pharma’s to realize commercialization and clinical uptake of our IP-protected MDC technology. During the ERC PoC project, we determine the optimal efficacy of MDC delivery, examine the concentration of the drug delivered to the tumor and other organs, validate the efficacy of MDC delivery in PDX mice after MDC treatment,and optimize our business case. This project will thus provide PROOF OF CONCEPT for the efficacy and pharmacokinetics of, and establish the viability, feasibility, commercialization and overall direction for our innovative MDC technology.
This project will substantially contribute to bring our MDC technology to the market and in clinical practice, where our MDC technology has the promising potential to improve prognosis of cancer patients, improve the performance of anti-cancer drugs, and reduce healthcare costs. THE NEW, INNOVATIVE MDC TECHNOLOGY CAN THUS REALIZE SIGNIFICANT BENEFITS FOR OUR SOCIETY AND OUR ECONOMY.
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Duración del proyecto: 29 meses
Fecha Inicio: 2020-07-20
Fecha Fin: 2022-12-31
Fecha Fin: 2022-12-31
Línea de financiación: concedida
El organismo H2020 notifico la concesión del proyecto el día 2022-12-31
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
ERC-2020-POC:
Call for proposals for ERC Proof of Concept Grant
Cerrada
hace 4 años
Presupuesto
El presupuesto total del proyecto asciende a
150K€
Líder del proyecto
SZKOLA GLOWNA GOSPODARSTWA WIEJSKIEGO
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5
575.35K€ |
Participante