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SILKink

Financiado

Revolutionary silk-based bioink for 3D printing of ex vivo bone marrow models to...

Revolutionary silk-based bioink for 3D printing of ex vivo bone marrow models to advance drug development and personalized medicine Aim: The SILKink project aims to develop a breakthrough biocompatible hydrogel, i.e., a bioink, to 3D print bone marrow tissue models that can be used for robust culture of human stem cells. The use of silk as the basis for novel... ver más

31/05/2026

UNIPV

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSITA DEGLI STUDI DI PAVIA No se ha especificado una descripción o un objeto social para esta compañía.

Ver 3 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-04-26

HORIZON-EIC-2022-TRANSITIONOPEN-01: EIC Transition Open 2022 Expected Impact:At the end of the EIC Transition project, it should be ready for the next stage, whi...

I+D

Cerrada hace 2 años

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3 Participantes

UNIPV

1.42M€ | Lider

CELLINK BIOPRINTING AB

897.50K€ | Participante

Catalyze B.V.

173.44K€ | Participante

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Duración del proyecto: 37 meses Fecha Inicio: 2023-04-26
Fecha Fin: 2026-05-31

Líder del proyecto

UNIVERSITA DEGLI STUDI DI PAVIA No se ha especificado una descripción o un objeto social para esta compañía.

Presupuesto del proyecto 2M€

Descripción del proyecto Aim: The SILKink project aims to develop a breakthrough biocompatible hydrogel, i.e., a bioink, to 3D print bone marrow tissue models that can be used for robust culture of human stem cells. The use of silk as the basis for novel bioinks (SILKink) helps to recreate tailored bone marrow-like microenvironments that will enable new applications in drug development and personalized medicine for bone marrow diseases. Here, we aim to optimize and validate SILKink, further define the business opportunity, and found an investment-ready spin-off company to commercialize SILKink. Unmet need: Bone marrow stem cells are fragile and require highly specific surroundings to survive and differentiate, therefore the presence of a soft tissue environment mimicking the human bone marrow is critical for reproducible culturing of these cells. There is a large unmet need for reproducible solutions that mimic the soft tissue of the bone marrow to allow advancements in drug development and personalized medicine approaches for bone marrow diseases. Solution: We will develop SILKink: a revolutionary bioink that is uniquely based on silk to closely mimic the 3D soft tissue environment of the bone marrow. SILKink will provide a matrix that supports all bone marrow cells including hematopoietic stem and progenitor cells and allows to 3D print ex vivo bone marrow stem cell models in the shape or volume desired. Consortium: University of Pavia (UNIPV) and partner CELLINK have developed the SILKink prototype during FET Open project SilkFUSION and co-own the background IP. Partner Catalyze-Group – Venture Building Team (CAT) will bring commercial expertise to develop an optimal market access strategy for SILKink. UNIPV will be responsible for SILKink optimization, manufacturing, and validation. CELLINK will be involved in product optimization and responsible for product development. CAT will assist UNIPV with founding a spin-off company to commercialize SILKink and making it investment-ready.

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