Innovating Works

3D-BrAIn

Financiado
Revolutionary high-resolution human 3D brain organoid platform integrating AI-ba...
Revolutionary high-resolution human 3D brain organoid platform integrating AI-based analytics The long-term vision of the 3D-BrAIn consortium is to revolutionize personalized precision medicine for central nervous system (CNS) disorders, by developing an innovative bio-digital twin model of the human brain that is personal... The long-term vision of the 3D-BrAIn consortium is to revolutionize personalized precision medicine for central nervous system (CNS) disorders, by developing an innovative bio-digital twin model of the human brain that is personalized, precise, and predictive. In this pathfinder project we bring together three breakthrough technologies: 1) a novel, highly reproducible human brain modelling technology using robust adherent iPSC-derived 3D cortical organoid cultures, 2) a unique, state-of-the-art 3D multi-electrode array (MEA) technology for non-invasive high-resolution electrophysiological recordings and 3) a novel approach to analyse and interpret the large quantities of functional data using tailored automated machine learning (ML)-based algorithms. With this breakthrough approach we overcome significant hurdles that made it thus far impossible to create a truly representative and functional model of the CNS for personalized medicine, drug screening and neurotoxicity testing. The revolutionary 3D-BrAIn high-precision CNS platform will allow robust and accurate modelling of the CNS for a broad range of neuropsychiatric diseases. Ultimately, the 3D-BrAIn technology will be translatable to multiple other organ systems (cardiomyocytes, pancreatic islets, retina), to non-invasively obtain longitudinal 3D high-resolution electrophysiological recordings and effectively interpret them. In this project a prototype of the 3D-BrAIn platform will be developed by growing functional 3D organoids that faithfully resemble the human cortex on 3D MEA micropillar electrodes, enabling continuous functional monitoring and by developing ML-based algorithms that can process and interpret the large spatiotemporal data sets. Once all individual components are optimized and integrated, proof-of-concept will be obtained by validating the platform for two of the envisaged applications: CNS drug development and neurotoxicity screening. ver más
31/03/2028
ERASMUS MC
2M€
Duración del proyecto: 64 meses Fecha Inicio: 2022-11-17
Fecha Fin: 2028-03-31

Línea de financiación: concedida

El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-11-17
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
HORIZON-EIC-2022-PATHFINDEROPEN-01-01: EIC Pathfinder Open 2022
Cerrada hace 2 años
Presupuesto El presupuesto total del proyecto asciende a 2M€
Líder del proyecto
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDA... No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5