HOPE
Financiado
Reverse engineering the assembly of the hippocampal scaffold with novel optical...
Reverse engineering the assembly of the hippocampal scaffold with novel optical and transgenic strategies
We aim at shedding a unique light on hippocampal function at circuit level through the design of a novel method to trace the construction of brain circuits in health and disease based on hybrid multiphoton in vivo longitudinal col...
We aim at shedding a unique light on hippocampal function at circuit level through the design of a novel method to trace the construction of brain circuits in health and disease based on hybrid multiphoton in vivo longitudinal color imaging of the dynamics and structure of genetically-tagged neuronal clones from birth into adulthood. This is made possible by the exceptional interdisciplinary collaboration of three labs with expertise in advanced optical microscopy, genetic engineering and systems developmental neuroscience. Our novel methodology, applied here to the hippocampus, will pioneer a new way to track the emergence and plasticity of heterogeneous neuronal circuits as these progressively give rise to function in physiological and pathological contexts, thus bridging the gap between early development and adult circuit physio-pathology. This will enable us to revisit adult hippocampal function from a developmental perspective. The hippocampus is classically described as providing a cognitive map of space, involved in navigation, learning, and episodic memory. However, a more computational and less representational vision of its role presently emerges in which its circuits are best described as producing sequences of neuronal activation arising from the interaction between external contextual inputs and internally-generated preconfigured dynamics. Converging work including ours leads us to hypothesize that internally preconfigured assemblies, shaped by their developmental journey, are the basic modules of hippocampal function. In this context, we will use our new approach to address three interrelated questions: 1) Are assemblies shaped by specific circuits in the adult hippocampus (objective A)? 2) Are they prewired or shaped by experience (objective B)? 3) What is their patho-physiological significance (objective C)? Addressing these major issues raises a timely challenge in both optics and genetic engineering at the core of this synergistic proposal.
ver más
Duración del proyecto: 75 meses
Fecha Inicio: 2021-03-22
Fecha Fin: 2027-06-30
Fecha Fin: 2027-06-30
Línea de financiación: concedida
El organismo H2020 notifico la concesión del proyecto el día 2021-03-22
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
ERC-2020-SyG:
ERC Synergy Grant
Cerrada
hace 5 años
Presupuesto
El presupuesto total del proyecto asciende a
9M€
Líder del proyecto
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE...
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5
430.66K€ |
Participante