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REPAIR

financed

RESTORING CARDIAC MECHANICAL FUNCTION BY POLYMERIC ARTIFICIAL MUSCULAR TISSUE

Heart Failure (HF) and Atrial Fibrillation (AF) are both associated with impairment of cardiac mechanical function. To assist ventricular contractility in HF, left ventricular assist devices (LVADs) have been developed and demonst... see more

31/05/2025

UNIFI

4M€

Project Budget: 4M€

Project leader

UNIVERSITA DEGLI STUDI DI FIRENZE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

Ver 11 Participantes

Financing granted El organismo H2020 notifico la concesión del proyecto The day 2020-06-22

FETPROACT-EIC-05-2019: FET Proactive: emerging paradigms a... Specific Challenge:To explore and consolidate a new technological direction in order to put it firml...

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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11 Participantes

UNIFI

1.08M€ | Leader

MEDTRONIC

502.97K€ | participant

USZ

230.00K€ | participant

TU Delft

301.47K€ | participant

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Project duration: 59 months Date Start: 2020-06-22
End date: 2025-05-31

Project leader

UNIVERSITA DEGLI STUDI DI FIRENZE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 4M€

participation deadline Sin fecha límite de participación.

Project description Heart Failure (HF) and Atrial Fibrillation (AF) are both associated with impairment of cardiac mechanical function. To assist ventricular contractility in HF, left ventricular assist devices (LVADs) have been developed and demonstrated able to reduce mortality in patients awaiting transplantation, but enormous disadvantages largely limit their long-term use. In parallel, promising devices to mechanically assist atrial contractile function have been successfully tested in large animals but never reached the clinical use. Our revolutionary idea to solve these clinical challenges is to exploit smart materials to support or restore the cardiac mechanical function. Among smart materials, liquid crystalline elastomers (LCEs) are able to respond to external stimuli in a reversible manner to generate movement or tension. The REPAIR consortium has recently developed a novel LCE-based artificial muscle that under external light stimulation is able to enhance cardiac muscle contraction. These results pave the way for the development of a novel generation of cardiac assist devices. We will first develop a mechanical performant and energetically efficient LCE material that, integrated with light sources (µLED array), will result in fundamental biomimetic contractile units to be structured in a suturable, remote controlled contractile tissue. The LCE-µLEDs contractile tissue will be exploited to develop a new generation of cardiac assist devices (e.g. ventriculoplasty patches, aortic rings for diastolic counterpulsation and epicardial bundles for atrial contraction assistance) and test the effects of their acute implantation in large mammals (open-chest sacrifice experiments) and human explanted hearts. Among LCE-device features: they will be self-contracting, low weight, associated with low thromboembolic risk, and most importantly, they will rely on a control unit that can modulate the exerted force providing the fist tunable cardiac assist device ever developed.

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