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Repurposing a known drug to treat heart diseases

Coronary Heart Disease (CHD) and particularly Myocardial Infarction (MI), i.e. heart attack, is the leading cause of death in the Western world today. The main cause for CHD is the incapacity of the mammalian heart to undergo rege... ver más

28/02/2022

WEIZMANN

150K€

Presupuesto del proyecto: 150K€

Líder del proyecto

WEIZMANN INSTITUTE OF SCIENCE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-02-28

ERC-2019-POC: ERC Proof of Concept Grant Scope:Eligible Countries

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2 Participantes

WEIZMANN

150.00K€ | Lider

INOXPA, S.A

266.02K€ | Participante

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Duración del proyecto: 22 meses Fecha Inicio: 2020-04-20
Fecha Fin: 2022-02-28

Líder del proyecto

WEIZMANN INSTITUTE OF SCIENCE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 150K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Coronary Heart Disease (CHD) and particularly Myocardial Infarction (MI), i.e. heart attack, is the leading cause of death in the Western world today. The main cause for CHD is the incapacity of the mammalian heart to undergo regeneration after injury. Current therapies are not able to address the central problem of decreased pumping capacity that results from the depleted pool of cardiac muscle cells. The outcome of this shortcoming is grim; nearly half of all patients with heart failure die within five years of the initial diagnosis. We have tested a widely used FDA approved drug, Copaxone, which is used to treat Multiple Sclerosis, for its efficacy in heart repair and made a breakthrough discovery. Copaxone improved cardiac function and reduced scarring in a mouse MI model. Most of the treated mice (85%) responded to the treatment, exhibiting an average improvement of 44% in heart function parameters, along with 40% reduction in scar size. In this PoC, we will expand these experiments by testing Copaxone using a chronic heart failure (CHF) model in both small and large animals (rats, pigs), and determine the optimal dosage regimen. Based on positive findings in this PoC, we plan to pursue Phase II clinical trials. The suggested activities include the preparation of the commercialization by interacting with key opinion leaders (e.g. cardiologists), who are in the position to speed up the clinical translation. We will also interact with pharma companies to build a potential collaborator and customer network. Eventually, we aim at commercializing repurposing existing drug to treat heart diseases, for CHF or acute MI indications. The impact of such therapy would be vast: CHD is the most common cause of death in Europe, accounting for 1.8 million deaths each year. As the original drug was already successfully commercialized by our institute, we can build on this experience and have the treatment available in approximately 5-6 years.

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