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PTSD Neurofeedback

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Regulating Pathological Neural Connectivity in Posttraumatic Stress Disorder

Posttraumatic stress disorder (PTSD) is a debilitating and prevalent psychiatric illness that develops after exposure to a traumatic event, and involves symptoms of severe intrusive recollections and flashbacks related to the trau... ver más

14/03/2022

UNIVIE

174K€

Presupuesto del proyecto: 174K€

Líder del proyecto

UNIVERSITAT WIEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-03-14

MSCA-IF-2019: Individual Fellowships Objective:The goal of the Individual Fellowships is to enhance the creative and innovative potential...

I+D

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Características del participante

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UNIVIE

174.17K€ | Lider

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Duración del proyecto: 24 meses Fecha Inicio: 2020-02-28
Fecha Fin: 2022-03-14

Líder del proyecto

UNIVERSITAT WIEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 174K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Posttraumatic stress disorder (PTSD) is a debilitating and prevalent psychiatric illness that develops after exposure to a traumatic event, and involves symptoms of severe intrusive recollections and flashbacks related to the trauma, hyperarousal and reactivity, avoidance, and negative alterations in cognitions and mood. Indeed, patients with PTSD are characterized by decreased prefrontal cortex (PFC) regulation on hyperactive emotion generation regions, such as the amygdala and brainstem. Real-time fMRI neurofeedback allows for brain regions to be self-regulated through neuroimaging signal feedback. Recently, the experienced researcher has shown that learning to decrease amygdala activation via real-time fMRI neurofeedback leads to a normalization of pathological neural circuitry maintaining PTSD, which was negatively correlated to symptoms. Critically, however, an intervention has not yet been developed to directly target suboptimal connectivity between emotion regulation regions (PFC) and emotion generation regions (amygdala and brainstem), where an urgent need for novel treatment interventions exists particularly among individuals suffering from PTSD. The objective of the current proposal is to determine the treatment efficacy of increasing the strength of connectivity from the PFC to the amygdala and brainstem via a real-time fMRI neurofeedback randomized clinical trial (RCT). Here, connectivity signals will be relayed back to the participant in the scanner as a simple thermometer that changes as directed connectivity between brain regions-of-interest fluctuate. Participants will be asked to self-regulate the neural signal displayed by the thermometer in real-time during PTSD emotion induction paradigms. The proposed study has the potential to develop into a novel treatment for PTSD, and is in line with current European research trends and societal needs to decrease the economic resources required to support mental health treatment.

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