Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

ReCaP

Financiado

Regeneration of Articular Cartilage using Advanced Biomaterials and Printing Tec...

Regeneration of Articular Cartilage using Advanced Biomaterials and Printing Technology Adult articular cartilage has a limited capacity for repair and when damaged or injured, experiences a loss of function which leads to joint degeneration and ultimately osteoarthritis. Biomaterials-based treatments have had very... ver más

31/07/2024

ROYAL COLLEGE OF S...

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

ROYAL COLLEGE OF SURGEONS IN IRELAND No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2024-07-31

ERC-2017-ADG: ERC Advanced Grant

I+D

Cerrada hace 7 años

0% 100% 100%

2 Participantes

ROYAL COLLEGE OF SURGEONS IN...

3.00M€ | Lider

ACEROS INOXIDABLES OLARRA

505.56K€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

ANCHOR Articular cartilage regeneration through the recruitment of... 150K€ Cerrado

JointPrinting 3D Printing of Cell Laden Biomimetic Materials and Biomolecu... 2M€ Cerrado

MAT2017-84361-R MATRICES DE REPROGRAMACION ACTIVADAS CON ARNM PARA INGENIERI... 121K€ Cerrado

SAF2017-83118-R ARQUITECTURAS POLIMERICAS 3D ACTIVAS PARA MEDICINA REGENERAT... 127K€ Cerrado

PID2020-113881RB-I00 ARQUITECTURAS 5D PARA MEDICINA REGENERATIVA Y TERAPIA LOCALI... 249K€ Cerrado

BES-2011-046144 DISEÑO Y FABRICACION DE UNA PLATAFORMA BIOMIMETICA TIPO SCAF... 43K€ Cerrado

Duración del proyecto: 73 meses Fecha Inicio: 2018-06-20
Fecha Fin: 2024-07-31

Líder del proyecto

ROYAL COLLEGE OF SURGEONS IN IRELAND No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Descripción del proyecto Adult articular cartilage has a limited capacity for repair and when damaged or injured, experiences a loss of function which leads to joint degeneration and ultimately osteoarthritis. Biomaterials-based treatments have had very limited success due to the complex zonal structure of the articular joint, problems with biomaterial retention at the joint surface and achieving integration with the host tissue while also maintaining load bearing capacity. Stem cell therapies have also failed to live up to significant hype for a number of reasons including the challenges with achieving formation of stable hyaline cartilage which does not undergo hypertrophy. Building on a wealth of experience in the area, we propose a solution. ReCaP will initially overcome the problems with traditional biomaterials approaches by utilising recent advances in the area of advanced manufacturing and 3D printing to develop a 3D printed multi-layered scaffold with pore architecture, mechanical properties and bioactive composition tailored to regenerate articular cartilage, intermediate calcified cartilage and subchondral bone. Following this, and building on internationally recognised pioneering research in the applicant’s lab on scaffold-mediated nanomedicine delivery, this system will be functionalised for the controlled non-viral delivery of nucleic acids (including plasmid DNA and microRNAs) to direct host stem cells to produce stable hyaline cartilage at the joint surface and encourage the rapid formation of vascularised bone in the subchondral region. A new paradigm-shifting surgical procedure will then be applied to allow this system to be anchored to the joint surface while directing host cell infiltration and tissue repair, thus promoting restoration of even large regions of the damaged joint through a joint surfacing approach. The proposed ReCaP platform is thus a paradigm shifting disruptive technology that will revolutionise the way joint injuries are treated.

Conecta tu I+D

Entra hoy

¿Olvide mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores