Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

De-StunHeartAttacks

Financiado

Re defining clinical care and reasoning in ST elevation myocardial infarction S...

Re defining clinical care and reasoning in ST elevation myocardial infarction STEMI by shifting focus to ischemic myocardial stunning Mechanisms prognostic implications and a new treatment Acute ischemic heart failure (AIHF) after ST-elevation myocardial infarction (STEMI) is a common and life-threatening condition for which the prognosis has not improved over the past decade, and for which no effective treatment op... ver más

31/10/2025

UGOT - GOETEBORGS...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

GOETEBORGS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-10-27

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2020-STG: ERC STARTING GRANTS

I+D

Cerrada hace 5 años

0% 100%

2 Participantes

UGOT - GOETEBORGS UNIVERSITE...

1.50M€ | Lider

TECSIDEL

470.76K€ | Participante

Proyectos interesantes

EUIN2013-51125 IMPROVING CLINICAL OUTCOMES IN ACUTE MYOCARDIAL INFARCTION:... 24K€ Cerrado

RTC-2017-6710-1 Apo J-Glyc en la isquemia cardiovascular (AGLIC) 440K€ Cerrado

SAF2013-49663-EXP INFARTO AGUDO DE MIOCARDIO: DETENER LA ISQVEMIA SIN RESTABLE... 99K€ Cerrado

PID2019-107332RB-I00 REEVALUACION DE LAS DIANAS TERAPEUTICAS EN EL DAÑO POR ISQUE... 375K€ Cerrado

EUIN2013-50881 OPTIMIZACION DE LA ADMINISTRACION DE METOPROLOL DURANTE EL I... 25K€ Cerrado

PROFID Implementation of personalised risk prediction and preventio... 23M€ Cerrado

Últimas noticias

27-11-2024: Videojuegos y creaci... Se abre la línea de ayuda pública: Ayudas para la promoción del sector del videojuego, del pódcast y otras formas de creación digital

27-11-2024: DGIPYME En las últimas 48 horas el Organismo DGIPYME ha otorgado 1 concesiones

27-11-2024: FUNDACION-EOI En las últimas 48 horas el Organismo FUNDACION EOI ha otorgado 2 concesiones

Duración del proyecto: 60 meses Fecha Inicio: 2020-10-27
Fecha Fin: 2025-10-31

Líder del proyecto

GOETEBORGS UNIVERSITET

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto Acute ischemic heart failure (AIHF) after ST-elevation myocardial infarction (STEMI) is a common and life-threatening condition for which the prognosis has not improved over the past decade, and for which no effective treatment option exists. Women, who have been underrepresented in most STEMI studies are more likely than men to develop AIHF after STEMI. My research aims to shift focus from traditional treatment targets (increased cardiac work and maintenance of blood pressure) to manipulation of myocardial stunning, the physiological phenomenon in which viable myocardium suddenly lose its function (becomes ‘stunned’) when exposed to a stressor (e.g. ischemia). Specifically, I aim to: 1) compare how stunning and propensity for AIHF affect prognosis for women vs. men with STEMI – using causal mediation analysis applied to a unique nationwide STEMI cohort (around 40,000 patients); 2) prospectively compare the rate of stunning resolution in STEMI patients with vs. without microvascular obstruction, in patients with STEMI vs. patients with takotsubo (another form of myocardial stunning with more favorable prognosis), and for women with STEMI vs. men with STEMI; 3) conduct a randomized controlled trial to assess the optimal timing of initiation of guideline-directed heart failure medications after STEMI; and 4) determine if pre-existing takotsubo-like stunning is protective in experimental AIHF. If my main hypothesis is correct, my this project could change the way researchers and clinicians approach the pathophysiology and treatment in STEMI. Irrespective of whether my main hypothesis is correct, my research proposal is designed to provide important insight into the pathophysiology and prognosis of myocardial stunning in STEMI, with a clear sex perspective that can help mitigate the sex gap in the level of evidence supporting the use and benefit of current treatments for STEMI.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores