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ProSPECT

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Promoting Synthetic Polyploid Engineering Commencing Technology

Polyploids, which result from Whole Genome Duplication (WGD) events, are thought to have enhanced adaptability which might explain why they are so pervasive in nature and especially in crop plants. Furthermore, polyploids exhibit... ver más

31/12/2023

ETH Zürich

191K€

Presupuesto del proyecto: 191K€

Líder del proyecto

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH No se ha especificado una descripción o un objeto social para esta compañía.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-12-31

MSCA-IF-2020: Individual Fellowships Objective:The goal of the Individual Fellowships is to enhance the creative and innovative potential...

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2 Participantes

ETH Zürich

191.15K€ | Lider

BODEGA MATARROMERA

216.76K€ | Participante

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Duración del proyecto: 32 meses Fecha Inicio: 2021-04-13
Fecha Fin: 2023-12-31

Líder del proyecto

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH No se ha especificado una descripción o un objeto social para esta compañía.

Presupuesto del proyecto 191K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Polyploids, which result from Whole Genome Duplication (WGD) events, are thought to have enhanced adaptability which might explain why they are so pervasive in nature and especially in crop plants. Furthermore, polyploids exhibit multiple advantages, from an agricultural perspective, such as often having larger fruits, and being more resilient to like drought and salinity. However, polyploidy requires evolving an adapted meiosis (well documented in natural polyploids) to cope with their additional chromosome sets during meiotic segregation; otherwise, resulting aneuploidies lead to genome instability and fertility problems. Because little is known about these adaptive mechanisms, the meiotic instability displayed by artificially generated (synthetic) polyploids (which lack of an evolved meiosis) cannot be eluded and the use of these synthetic polyploids remains exceptional as a tool to generate novel crop varieties. It is expected that regulating meiotic crossovers to prevent formation of multivalent associations among more than two homologous chromosomes during meiosis would decisively improve segregation and fertility of synthetic polyploids. While compelling, this hypothesis has not been formally tested. ProSPECT aims to address the problem of genome instability in synthetic polyploids by testing the viability of two strategies to artificially induce meiotic adjustments that might improve chromosome segregation using Arabidopsis thaliana polyploid mutants as a proof of concept. To do so I will use two strategies: (a) First, I will use meiotic recombination mutants known to reduce the number of meiotic crossovers to test if this is sufficient to limit the chances for multivalent formation in A. thaliana synthetic polyploid inbreds. (b) Second, I will use polyploid hybrids carrying combinations of meiotic mutants known to restrict meiotic crossovers to (nearly) identical partners to test if this is sufficient to impede associations among more than two chromosomes.

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