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PANA

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PROMOTING ACTIVE AGEING FUNCTIONAL NANOSTRUCTURES FOR ALZHEIMER S DISEASE AT UL...

PROMOTING ACTIVE AGEING FUNCTIONAL NANOSTRUCTURES FOR ALZHEIMER S DISEASE AT ULTRA EARLY STAGES. Alzheimer’s disease (AD) is the leading cause of dementia and loss of autonomy in the elderly, implying a progressive cognitive decline and limitation of social activities. Progressive aging of EU population will increase the magn... ver más

31/08/2021

SERVICIO GALEGO DE...

8M€

Presupuesto del proyecto: 8M€

Líder del proyecto

SERVICIO GALEGO DE SAUDE SERGAS Actividades generales de la administración pública organismos publicos

TRL 4-5 | 50K€

Fecha límite participación Sin fecha límite de participación.

Ver 13 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-08-31

NMP-12-2015: Biomaterials for treatment and prev...

I+D

Cerrada hace 9 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

13 Participantes

SERVICIO GALEGO DE SAUDE SER...

1.57M€ | Lider

STICHTING AMSTERDAM UMC

762.13K€ | Participante

KU Leuven

1.09M€ | Participante

UNIVERSITY OF EASTERN FINLAN...

1.06M€ | Participante

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Duración del proyecto: 65 meses Fecha Inicio: 2016-03-04
Fecha Fin: 2021-08-31

Líder del proyecto

SERVICIO GALEGO DE SAUDE SERGAS Actividades generales de la administración pública organismos publicos

TRL 4-5 | 50K€

Presupuesto del proyecto 8M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Alzheimer’s disease (AD) is the leading cause of dementia and loss of autonomy in the elderly, implying a progressive cognitive decline and limitation of social activities. Progressive aging of EU population will increase the magnitude of this problem in the next decades. Currently, there is not an effective method for the early diagnosis of AD. Therefore, there is an urgent need to develop new effective early diagnostic and therapeutic strategies to help in delaying the appearance of the most adverse symptoms of this disease. To defeat this challenge, PANA project bases its approach on the importance of tau oligomers in the early pathophysiological processes of AD. The effective strategy will be based on two fundamental pillars; on one hand, efforts will be focused on multimodal PET/MRI imaging which is gaining relevance as the best solution for diagnostic purposes due to the complementary advantages of both technologies, combining the high structural characterization of tissue provided by MRI with the enhanced sensitivity of PET imaging. On the other hand, the challenging development of a theragnostic nanostructures will be focused on tau oligomers detection, which would have to deliver theragnostic agents into the brain to provide in situ diagnostic and therapeutic effects. Therefore, PANA project focuses on developing theranostic nanostructures that specifically recognize very-early molecular markers of AD, and can be detected by means of non-invasive imaging methodologies (MRI and/or PET, which are already common techniques accessible in most hospitals) and eventually provide a therapeutic action if needed. To achieve this goal, we propose a unique consortium which combines neuroscientists, nanotechnologists, molecular imaging experts, clinicians and Small/Medium/Large Enterprises in an effort to use smart nanoparticles engineered with multifunctional biomaterial to provide new very-early diagnostic tools for AD, a vital medical/social problem in EU.

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