Programmable nucleic acid toolkits for cell free diagnostics and genetically enc...
Programmable nucleic acid toolkits for cell free diagnostics and genetically encoded biosensing
WHY: The biological complexity of tumours and the large diversity of diagnostic biomarkers call for the development of innovative analytical tools that can detect multiple targets in a sensitive, specific and low-cost way and allo...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Proyectos interesantes
ENZYME-SWITCHES
Enzyme conjugated DNA nanoswitches for biosensing applicatio...
168K€
Cerrado
MAT2012-38573-C02-01
PLATAFORMAS DE DIAGNOSTICO UNIVERSAL BASADAS EN NANOPARTICUL...
121K€
Cerrado
PID2021-123183OB-I00
PLATAFORMAS SENSORAS ELECTROQUIMICAS BASADAS EN ACIDOS NUCLE...
169K€
Cerrado
NADINE
Nanosystems for the early Diagnosis of Neurodegenerative dis...
12M€
Cerrado
BES-2015-071312
ACIDOS NUCLEICOS SINTETICOS PARA APLICACIONES BIOMEDICAS
93K€
Cerrado
TEC2012-34280
INTEGRACION LAB-ON-A-CHIP DE DISPOSITIVOS BIOFOTONICOS PARA...
138K€
Cerrado
Información proyecto PRO-TOOLKITS
Duración del proyecto: 78 meses
Fecha Inicio: 2019-03-22
Fecha Fin: 2025-09-30
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
WHY: The biological complexity of tumours and the large diversity of diagnostic biomarkers call for the development of innovative analytical tools that can detect multiple targets in a sensitive, specific and low-cost way and allow real-time monitoring of disease pathways and therapeutic effects. To provide such transformative tools creative thinking, innovative approach and the exploration of new research avenues that span different disciplines is necessary.
WHAT: The goal of the PRO-TOOLKITS project is to address this need by developing innovative cell-free point of care diagnostic kits and genetically encodable biosensing tools.
HOW: I oriented my independent career as a P.I. towards the design and development of synthetic nucleic acid-based nanodevices and nanomachines. With the help of an ERC Starting Grant I made ground-breaking contributions in the field of nucleic acid Nanotechnology. Motivated by these advancements I propose to challenge my know-how and expertise to explore new research avenues that will open exciting possibilities in biosensing applications. The key, ground-breaking IDEA underlying this project is to take advantage of my expertise and harness the advantageous features of RNA synthetic modules that can translate the expression of proteins in controlled in-vitro cell-free systems and can be also genetically encoded in living organisms and function inside the cells. I will develop rationally designed programmable nucleic acid modules that respond to a wide range of molecular markers and environmental stimuli through innovative nature-inspired mechanisms and that can be orthogonally wired to provide cell-free diagnostic kits and genetically encoded live-cell biosensing tools. The project will provide transformative approaches, methods and tools that will represent a genuine break-through in the fields of in-vitro diagnostics, biosensing and synthetic biology.