Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

BioCircuit

Financiado

Programmable BioMolecular Circuits Emulating Regulatory Functions in Living Cel...

Programmable BioMolecular Circuits Emulating Regulatory Functions in Living Cells Using a Bottom Up Approach Programmable biomolecular circuits have received increasing attention in recent years as the scope of chemistry expands from the synthesis of individual molecules to the construction of chemical networks that can perform sophistic... ver más

31/01/2022

TU/e

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

TECHNISCHE UNIVERSITEIT EINDHOVEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-01-31

ERC-StG-2015: ERC Starting Grant

I+D

Cerrada hace 9 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

TU/e

1.89M€ | Lider

APLICACIONES INDUSTRIALES DE...

116.40K€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

BIO2008-04856 SISTEMAS ARTIFICIALES BIOCATALITICOS REPLICATIVOS 145K€ Cerrado

PID2021-127888NA-I00 DISEÑO, ANALISIS Y CONTROL AVANZADOS DE CIRCUITOS BIOMOLECUL... 169K€ Cerrado

PID2020-118436GB-I00 CIRCUITOS GENETICOS ADAPTATIVOS 169K€ Cerrado

BIO2011-28941-C03-03 BIOLOGIA SINTETICA DE LA DIVISION: CONSTRUCCION DE DIVISOMAS... 260K€ Cerrado

TIN2012-36992 PROGRAMACION E INGENIERIA DE BIOCIRCUITOS: DISEÑO Y MODELADO... 156K€ Cerrado

CTQ2017-89539-P LIBRERIAS CONSTITUCIONALES DINAMICAS CON PROPIEDADES "CELULA... 62K€ Cerrado

Duración del proyecto: 70 meses Fecha Inicio: 2016-03-08
Fecha Fin: 2022-01-31

Líder del proyecto

TECHNISCHE UNIVERSITEIT EINDHOVEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto Programmable biomolecular circuits have received increasing attention in recent years as the scope of chemistry expands from the synthesis of individual molecules to the construction of chemical networks that can perform sophisticated functions such as logic operations and feedback control. Rationally engineered biomolecular circuits that robustly execute higher-order spatiotemporal behaviours typically associated with intracellular regulatory functions present a unique and uncharted platform to systematically explore the molecular logic and physical design principles of the cell. The experience gained by in-vitro construction of artificial cells displaying advanced system-level functions deepens our understanding of regulatory networks in living cells and allows theoretical assumptions and models to be refined in a controlled setting. This proposal combines elements from systems chemistry, in-vitro synthetic biology and micro-engineering and explores generic strategies to investigate the molecular logic of biology’s regulatory circuits by applying a physical chemistry-driven bottom-up approach. Progress in this field requires 1) proof-of-principle systems where in-vitro biomolecular circuits are designed to emulate characteristic system-level functions of regulatory circuits in living cells and 2) novel experimental tools to operate biochemical networks under out-of-equilibrium conditions. Here, a comprehensive research program is proposed that addresses these challenges by engineering three biochemical model systems that display elementary signal transduction and information processing capabilities. In addition, an open microfluidic droplet reactor is developed that will allow, for the first time, high-throughput analysis of biomolecular circuits encapsulated in water-in-oil droplets. An integral part of the research program is to combine the computational design of in-vitro circuits with novel biochemistry and innovative micro-engineering tools.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores